Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Enzinger, C; Ropele, S; Smith, S; Strasser-Fuchs, S; Poltrum, B; Schmidt, H; Matthews, PM; Fazekas, F.
Accelerated evolution of brain atrophy and black holes in MS patients with APOE-epsilon 4.
ANN NEUROL. 2004; 55: 563-569.
Doi: 10.1002/ana.20027
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Enzinger Christian
- Fazekas Franz
- Co-Autor*innen der Med Uni Graz
- Fuchs Siegrid
- Poltrum Birgit
- Ropele Stefan
- Schmidt Helena
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Apolipoprotein E (APOE)-epsilon4 has been associated with an unfavorable course of multiple sclerosis (MS). The mechanisms responsible for this are unclear, although cross-sectional MRI demonstrated a higher extent of "black holes" (BHs) in such patients. Here, we have studied the impact of the APOE genotype on both the longitudinal evolution of focal (BH ratio) and global (brain volume change [BVC]) brain tissue damage. Ninety-nine MS patients underwent ApoE genotyping, clinical examination, and magnetic resonance imaging at baseline and after 2.7 +/- 1.1 years to assess lesion load (LL) and BVC. In APOE-epsilon4 patients, the annual reduction in brain volume was fivefold higher (-0.65 +/- 0.61%) than in those without APOE-epsilon4 (-0.13 +/- 0.36%; p = 0.0001). At baseline, T(2) LL and T(1) LL were non-significantly higher in epsilon4 carriers, despite a shorter disease duration and absence of significant clinical differences. During follow-up, T(1) LL increased from 1.2 +/- 2.3 ccm to 1.7 +/- 2.7 ccm in the epsilon4 group, although T(2) LL did not change, leading to a significantly higher increase in the BH ratio [(T(1) LL/T(2) LL) x 100] from 5.5 to 12.4% (p = 0.005). BH ratio remained almost constant in non-epsilon4 patients (5.0 vs 5.7%). Accelerated brain tissue loss and a higher proportion of lesions evolving into BH therefore provide magnetic resonance imaging evidence for more pronounced tissue destruction in MS patients with APOE-epsilon4.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Analysis of Variance -
- Apolipoprotein E4 -
- Apolipoproteins E - genetics
- Atrophy - genetics
- Brain - pathology
- Female - pathology
- Follow-Up Studies - pathology
- Genotype - pathology
- Humans - pathology
- Magnetic Resonance Imaging - methods
- Male - methods
- Middle Aged - methods
- Multiple Sclerosis - genetics
- Multivariate Analysis - genetics
- Statistics, Nonparametric - genetics