Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Eder, HG; Feichtinger, M; Pieper, T; Kurschel, S; Schroettner, O.
Gamma knife radiosurgery for callosotomy in children with drug-resistant epilepsy.
CHILD NERV SYST. 2006; 22(8): 1012-1017.
Doi: 10.1007/s00381-006-0138-z
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Eder Hans
- Co-Autor*innen der Med Uni Graz
- Feichtinger Michael
- Kurschel-Lackner Senta
- Schroettner Oskar
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- Abstract:
- OBJECTIVES: Gamma knife radiosurgery as a noninvasive procedure is increasingly used as a treatment option in patients with intractable seizures. We investigated efficacy and safety of gamma knife radiosurgery (GKRS) for callosotomy in children. MATERIALS AND METHODS: Between 2000 and 2004 three children between 4 and 14 years (mean 8 years) underwent radiosurgical callosotomy. One child presented with Lennox-Gastaut syndrome, two with hemispheric cortical dysplasia. These two children underwent functional hemispherotomy before GKRS. GKRS was performed with a marginal dose of 55-60 Gy on the 50% isodose. RESULTS: Mean follow-up was 35 months. Radiosurgical callosotomy was ineffective in one child with the Lennox-Gastaut syndrome, whereas in the remaining two children, a 100% seizure reduction of generalized tonic-clonic seizures, 20-70% reduction of partial seizures, and a progress in mental and physical development was achieved. No postradiosurgical side effects were observed in all children. CONCLUSION: Radiosurgical callosotomy might be offered after hemispherotomy to complete callosal resection. However, larger number of patients and longer follow-ups are needed to draw final conclusions.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Child -
- Child, Preschool -
- Corpus Callosum - surgery
- Drug Resistance - surgery
- Epilepsy - drug therapy
- Female - drug therapy
- Humans - drug therapy
- Magnetic Resonance Imaging - drug therapy
- Male - drug therapy
- Radiosurgery - methods
- Retrospective Studies - methods
- Treatment Outcome - methods
- Find related publications in this database (Keywords)
- gamma knife
- radiosurgery
- epilepsy
- callosotomy
- children
- hemispherotomy