Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Weber-Mzell, D; Kotanko, P; Hauer, AC; Goriup, U; Haas, J; Lanner, N; Erwa, W; Ahmaida, IA; Haitchi-Petnehazy, S; Stenzel, M; Lanzer, G; Deutsch, J.
Gender, age and seasonal effects on IgA deficiency: a study of 7293 Caucasians.
EUR J CLIN INVEST. 2004; 34(3): 224-228.
Doi: 10.1111/j.1365-2362.2004.01311.x
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- Führende Autor*innen der Med Uni Graz
- Sperl Daniela Ingrid
- Co-Autor*innen der Med Uni Graz
- Deutsch Johann
- Erwa Wolfgang
- Haas Josef
- Hauer Almuthe
- Lanner Natalie Maria
- Lanzer Gerhard
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- Abstract:
- The frequency of serum IgA deficiency (SIgAD) differs between populations. We examined the prevalence of SIgAD in healthy Caucasians. Serum immunoglobulin A (SIgA) was measured in 7293 volunteers (2264 women, 5029 men) aged 30 +/- 14.2 years (mean +/- SD; range: 12-66). Serum immunoglobulin A and subnormal SIgA levels were defined by a SIgA level < 0.07 g L(-1), and between 0.07 and 0.7 g L(-1), respectively. Means were compared by analysis of variance (anova) and analysis of covariance (ancova); frequencies by the chi(2) test. Fifteen subjects (0.21%; one woman, 14 men) had SIgAD. Subnormal SIgA levels were found in 155 persons (2.13%): 21 females (0.93% of the females) and 134 males (2.66% of the males; difference: 1.74%; 95% CI: 1.12-2.33%; P < 0.001). Males were more likely to have subnormal SIgA levels or SIgAD (odds ratio 3.09, 95% CI: 1.97-4.85). The prevalence of SIgAD and subnormal SIgA was lowest in winter (chi(2) = 14.8; P = 0.002; 3 d.f.; and chi(2) = 43.2; P < 0.001; 3 d.f., respectively). Serum immunoglobulin A concentrations were significantly higher during winter. Serum immunoglobulin A levels increased with age on average by 0.2 +/- 0.06 g L(-1) per decade of life (P < 0.001). Taking into account the influence of age, SIgA concentration was lower in females as compared with males. The prevalence of SIgAD and subnormal SIgA levels is increased in males. There exists a significant influence of gender, age and seasons on SIgA levels.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Age Factors -
- Aged -
- Aging - immunology
- Austria - epidemiology
- Child - epidemiology
- Female - epidemiology
- Humans - epidemiology
- IgA Deficiency - epidemiology
- Immunoglobulin A - blood
- Male - blood
- Middle Aged - blood
- Prevalence - blood
- Reference Values - blood
- Seasons - blood
- Sex Factors - blood
- Find related publications in this database (Keywords)
- age- and gender-related variability
- immunoglobulin A
- seasonal variability
- serum IgA deficiency