Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Benesch, M; Urban, C; Sykora, KW; Schwinger, W; Zintl, F; Lackner, H; Lang, P; Handgretinger, R.
Transplantation of highly purified CD34+ progenitor cells from alternative donors in children with refractory severe aplastic anaemia.
BRIT J HAEMATOL. 2004; 125(1): 58-63.
Doi: 10.1111/j.1365-2141.2004.04857.x
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- Führende Autor*innen der Med Uni Graz
- Benesch Martin
- Co-Autor*innen der Med Uni Graz
- Lackner Herwig
- Schwinger Wolfgang
- Urban Ernst-Christian
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- Abstract:
- Without transplantation from a human leucocyte antigen-identical family donor, refractory severe aplastic anaemia (SAA) has an unfavourable prognosis. Conventional transplantation from a matched unrelated donor carries a high rate of mortality. We transplanted large numbers of highly purified CD34+ cells from matched unrelated (n = 4), mismatched unrelated (n = 4) and mismatched related (n = 1) donors into nine children with refractory SAA. The grafts consisted of granulocyte colony-stimulating factor-mobilized peripheral positively selected CD34+ cells. A median of 15.1 x 106/kg CD34+ stem cells and 11 x 103/kg CD3+ T-lymphocytes were infused. No additional pharmacological graft versus host disease (GVHD) prophylaxis was given. At a median follow-up of 47 (range 37-72) months, eight patients (89%) were in complete remission with >90% donor chimaerism and no evidence of GVHD. One patient died on day +238 as a consequence of GVHD. The use of highly purified mobilized CD34+ stem cells warrants further clinical exploration in children with refractory SAA.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Anemia, Aplastic - therapy
- Anemia, Refractory - therapy
- Antigens, CD34 - blood
- Cell Separation - methods
- Child - methods
- Female - methods
- Graft Rejection - prevention and control
- Graft vs Host Disease - prevention and control
- Hematopoietic Stem Cell Transplantation - methods
- Hematopoietic Stem Cells - immunology
- Histocompatibility - immunology
- Humans - immunology
- Male - immunology
- Transplantation Conditioning - methods
- Find related publications in this database (Keywords)
- severe aplastic anaemia
- alternative donors
- CD34(+) selection