Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wolf, P; Seidl, H; Bäck, B; Binder, B; Höfler, G; Quehenberger, F; Hoffmann, C; Kerl, H; Stark, S; Pfister, HJ; Fuchs, PG.
Increased prevalence of human papillomavirus in hairs plucked from patients with psoriasis treated with psoralen-UV-A.
ARCH DERMATOL. 2004; 140(3): 317-324.
Doi: 10.1001/archderm.140.3.317
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Wolf Peter
- Co-Autor*innen der Med Uni Graz
- Binder Barbara
- Höfler Gerald
- Kerl Helmut
- Quehenberger Franz
- Seidl Hannes
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: Patients with psoriasis treated with psoralen-UV-A (PUVA) are at increased risk of skin cancer; however, the exact causes of this increased incidence are not well understood. It has been suggested that PUVA may increase expression of the tumorigenic agent human papillomavirus (HPV) in skin by directly stimulating virus replication, immune suppression, or both, thereby leading to skin cancer formation. OBJECTIVE: To determine whether HPV DNA prevalence in the skin is increased after long-term PUVA treatment. DESIGN: Screening for the presence of HPV sequences in DNA isolated from plucked body hairs of patients with psoriasis with a history of PUVA exposure and a history of skin cancer (group A), PUVA exposure and no history of skin cancer (group B), and no PUVA exposure and no history of skin cancer (group C). SETTING: University hospital.Patients and METHODS: Hair samples were obtained from 81 patients with psoriasis (56 men and 25 women; mean age, 52 years), including 16 in group A (mean number of PUVA exposures, 702), 35 in group B (mean number of PUVA exposures, 282), and 30 in group C. DNA was isolated from the hair samples and analyzed by polymerase chain reaction with the use of 2 nested primer systems specific for epidermodysplasia verruciformis-associated or related and genital or mucosal virus types, respectively. RESULTS: The rate of HPV DNA positivity was significantly higher in groups A (73% [11/15]) and B (69% [24/35]) than in group C (36% [10/28]) (A + B vs C, P =.009; chi(2) test; age adjusted).Conclusion The prevalence of HPV in the skin (hair follicles) is increased in patients with psoriasis who have a history of PUVA exposure.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Austria - epidemiology
- Case-Control Studies - epidemiology
- DNA, Viral - analysis
- Female - analysis
- Ficusin - administration and dosage
- Hair - virology
- Humans - virology
- Male - virology
- Middle Aged - virology
- PUVA Therapy - adverse effects
- Papillomaviridae - classification
- Photosensitizing Agents - administration and dosage
- Prevalence - administration and dosage
- Psoriasis - drug therapy