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Kratz, M; Cullen, P; Kannenberg, F; Kassner, A; Fobker, M; Abuja, PM; Assmann, G; Wahrburg, U.
Effects of dietary fatty acids on the composition and oxidizability of low-density lipoprotein.
EUR J CLIN NUTR 2002 56: 72-81. Doi: 10.1038/sj.ejcn.1601288 [OPEN ACCESS]
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Co-authors Med Uni Graz: Abuja Peter Michael
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Abstract:: OBJECTIVE: The objective of this study was to compare the effects of dietary monounsaturated fatty acids (MUFA), n-6 and n-3 polyunsaturated fatty acids (PUFA) on LDL composition and oxidizability. DESIGN, SETTING AND SUBJECTS: Sixty-nine healthy young volunteers, students at a nearby college, were included. Six subjects withdrew because of intercurrent illness and five withdrew because they were unable to comply with the dietary regimen. INTERVENTIONS: The participants received a 2-week wash-in diet rich in saturated fatty acids (SFA) followed by diets rich in refined olive oil, rapeseed oil or sunflower oil for 4 weeks. Intakes of vitamin E and other antioxidants did not differ significantly between the diets. RESULTS: At the end of the study, LDL oxidizability was lowest in the olive oil group (lag time: 72.6 min), intermediate in the rapeseed oil group (68.2 min) and highest in the sunflower oil group (60.4 min, P<0.05 for comparison of all three groups). Despite wide variations in SFA intake, the SFA content of LDL was not statistically different between the four diets (25.8-28.5% of LDL fatty acids). By contrast, the PUFA (43.5%-60.5% of LDL fatty acids) and MUFA content of LDL (13.7-29.1% of LDL fatty acids) showed a wider variability dependent on diet. CONCLUSIONS: Enrichment of LDL with MUFA reduces LDL susceptibility to oxidation. As seen on the rapeseed oil diet this effect is independent of a displacement of higher unsaturated fatty acids from LDL. Evidence from this diet also suggests that highly unsaturated n-3 fatty acids in moderate amounts do not increase LDL oxidizability when provided in the context of a diet rich in MUFA.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Body Weight - physiology; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Diet Records - blood; Dietary Fats, Unsaturated - administration and dosage; Energy Intake - physiology; Fatty Acids, Monounsaturated - administration and dosage; Fatty Acids, Unsaturated - administration and dosage; Female - administration and dosage; Humans - administration and dosage; Male - administration and dosage; Plant Oils - administration and dosage; Reference Values - administration and dosage; Tocopherols - blood; Triglycerides - blood
Find related publications in this database (Keywords): LDL; arteriosclerosis; diet; lipoproteins; nutrition