Medizinische Universität Graz - Research portal
Selected Publication:
Abuja, PM.
Aggregation of LDL with chondroitin-4-sulfate makes LDL oxidizable in the presence of water-soluble antioxidants.
FEBS Lett. 2002; 512(1-3):245-248
Doi: 10.1016/S0014-5793(02)02273-1
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- Leading authors Med Uni Graz
- Abuja Peter Michael
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- Abstract:
- The content of plasma and arterial interstitial fluid in water-soluble antioxidants makes it unlikely for low-density lipoprotein (LDL) to oxidize by the oxidation mechanisms most frequently discussed. By aggregation of LDL in the presence of chondroitin-4-sulfate (C-4-S), but not with chondroitin-6-sulfate or sphingomyelinase, a complex arises which can oxidize in the presence of 20 microM ascorbate and 300 microM urate. This oxidation sensitivity even persists after the gel-filtration of an LDL/C-4-S/Cu(2+) complex, indicating entrapment of Cu(2+) within. This corresponds well to the known ability of C-4-S to bind copper ions and is a potential mechanism by which LDL oxidation in the arterial intima is facilitated after prolonged retention by the extracellular matrix.
- Find related publications in this database (using NLM MeSH Indexing)
- Antioxidants - pharmacology
- Chondroitin Sulfates - metabolism
- Humans - metabolism
- Lipid Peroxidation - metabolism
- Lipoproteins, LDL - metabolism
- Solubility - metabolism
- Water - metabolism
- Find related publications in this database (Keywords)
- atherosclerosis
- lipid peroxidation
- antioxidant
- extracellular matrix
- glycosaminoglycan
- chondroitin-4-sulfate