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Selected Publication:
Albertini, R; De Luca, G; Palladini, G; Passi, A; Melzi d'Eril, GV; Abuja, PM.
Mechanistic aspects of the relationship between low-level chemiluminescence and lipid peroxides in oxidation of low-density lipoprotein.
FEBS LETT 1999 459: 47-50.
Doi: 10.1016/S0014-5793(99)01217-X
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- Co-authors Med Uni Graz
- Abuja Peter Michael
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- Abstract:
- In this study oxidation of low-density lipoprotein (LDL) induced by different Cu2+ concentrations was investigated. Lipid peroxidation was assessed by monitoring low-level chemiluminescence (LL-CL), conjugated diene hydroperoxide (CD) and alpha-tocopherol (TocOH), the major lipophilic antioxidant in LDL. At high Cu2+ concentration, LDL oxidation was characterised by CD formation, LL-CL emission and TocOH consumption. At low Cu2+ concentration, CD formation was independent of LL-CL and occurred in the presence of TocOH. Thus, two different mechanisms lead to lipid peroxide formation in LDL. The combination of CD assay and LL-CL monitoring makes it possible to distinguish the autocatalytic mechanism of CD formation and that associated with TocOH, found at a high and a low rate of initiation, respectively.
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- Hydrogen Peroxide - chemistry
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- Lipoproteins, LDL - metabolism
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- Find related publications in this database (Keywords)
- low-density lipoprotein
- lipid peroxidation
- low-level chemiluminescence
- tocopherol