Medizinische Universität Graz - Research portal
Selected Publication:
Feichtenhofer, S; Fabjan, JS; Abuja, PM.
Ceruloplasmin as low-density lipoprotein oxidase: activation by ascorbate and dehydroascorbate.
FEBS LETT 2001 501: 42-46.
Doi: 10.1016/S0014-5793(01)02623-0
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- Leading authors Med Uni Graz
- Abuja Peter Michael
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- Abstract:
- The ability of ceruloplasmin (Cp) to oxidize low-density lipoproteins (LDL) in the presence of water-soluble antioxidants was investigated and a reaction mechanism proposed. Ascorbate strongly enhanced LDL oxidation, but only after its rapid consumption. Dehydroascorbate enhanced Cp-mediated LDL oxidation even more strongly. Lipid-soluble antioxidants and water-soluble peroxides did not show noticeable activation. However, loading of LDL with lipid hydroperoxides increased the initial oxidation rate. We conclude that Cp mediates a localized redox cycle, where reduction of Cp-Cu2+ is effected by water-soluble reductants and reoxidation by liposoluble hydroperoxides.
- Find related publications in this database (using NLM MeSH Indexing)
- Antioxidants - metabolism
- Ascorbic Acid - metabolism
- Ceruloplasmin - metabolism
- Copper - metabolism
- Dehydroascorbic Acid - metabolism
- Enzyme Activation - drug effects
- Female - drug effects
- Humans - drug effects
- Lipid Peroxides - metabolism
- Lipoproteins, LDL - metabolism
- Male - metabolism
- Oxidation-Reduction - drug effects
- Reducing Agents - metabolism
- Solubility - metabolism
- Vitamin E - metabolism
- Water - metabolism
- Find related publications in this database (Keywords)
- low-density lipoprotein
- ceruloplasmin
- plasma antioxidant
- 15-lipoxygenase
- lipid peroxidation
- atherosclerosis