Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Ohm, TG; Kirca, M; Bohl, J; Scharnagl, H; Gross, W; März, W.
Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation.
NEUROSCIENCE 1995 66: 583-587.
Doi: 10.1016/0306-4522(94)00596-W
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- Co-Autor*innen der Med Uni Graz
- März Winfried
- Scharnagl Hubert
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- Abstract:
- Only recently, evidence was provided that apolipoprotein E allele epsilon 4 located on Chromosome 19 is associated with late onset (i.e. senile) sporadic Alzheimer's disease. Histologically, Alzheimer's disease is associated with intraneuronal neurofibrillary changes and extraneuronal A4/beta-amyloid deposition. We set out with a histological staging system which considers the gradual development of Alzheimer's disease-related histological changes over time and correlates highly with the cognitive decline ante mortem. Our analysis revealed that both the mean stage for A4/beta-amyloid deposits and the mean stage for neurofibrillary tangles get significantly shifted upwards in epsilon 4-carriers. This represents an earlier onset of the histopathological process of about one decade. The fact that both types of Alzheimer's disease-related changes correlate positively with the prevalence of the epsilon 4-allele suggests for a causal relationship between the apolipoprotein E polymorphism and the development of Alzheimer's disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Age Factors -
- Aged -
- Aged, 80 and over -
- Alleles -
- Alzheimer Disease - genetics
- Amyloid beta-Protein - analysis
- Apolipoproteins E - genetics
- Brain - pathology
- Chromosomes, Human, Pair 19 - pathology
- Comparative Study - pathology
- Genotype - pathology
- Humans - pathology
- Middle Aged - pathology
- Neurofibrillary Tangles - pathology
- Polymorphism, Genetic - pathology
- Regression Analysis - pathology
- Research Support, Non-U.S. Gov't - pathology