Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Vejda, S; Posovszky, C; Zelzer, S; Peter, B; Bayer, E; Gelbmann, D; Schulte-Hermann, R; Gerner, C.
Plasma from cancer patients featuring a characteristic protein composition mediates protection against apoptosis.
MOL CELL PROTEOMICS. 2002; 1: 387-393.
Doi: 10.1074/mcp.200004-MCP200
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- Co-Autor*innen der Med Uni Graz
- Zelzer Sieglinde
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- Abstract:
- By comparative proteome analysis we searched for characteristic alterations of human plasma accompanying neoplastic disease. We identified protein alterations in plasma of prostate-, lung-, and breast-cancer patients in comparison to controls, comprising elevated levels of fibrinogen gamma-chain dimer, degradation products of antiplasmin and laminin gamma-chain, and elevated levels of acute phase proteins. The latter proteins and laminin fragments have been described as anti-apoptotic factors. We raised the question whether these alterations may have any relevance for the regulation of apoptosis. In contrast to plasma derived from healthy donors, samples from prostate-, lung-, and breast-cancer patients selectively inhibited Fas- and staurosporine-induced apoptosis in Jurkat cells but remained ineffective upon UV light-induced apoptosis. These data suggested that inhibition occurred by extracellular interference with apoptosis induction. Supporting this hypothesis, we found that formation of the CD95 death-inducing signal complex was strongly inhibited in the presence of plasma from cancer patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Antigens, CD95 - biosynthesis
- Antiplasmin - biosynthesis
- Apoptosis - biosynthesis
- Blotting, Western - biosynthesis
- Breast Neoplasms - blood
- Caspases - biosynthesis
- Dimerization - biosynthesis
- Electrophoresis, Polyacrylamide Gel - biosynthesis
- Female - biosynthesis
- Fibrinogen - biosynthesis
- Humans - biosynthesis
- Jurkat Cells - biosynthesis
- Laminin - blood
- Lung Neoplasms - blood
- Male - blood
- Neoplasms - blood
- Precipitin Tests - blood
- Prostatic Neoplasms - blood
- Research Support, Non-U.S. Gov't - blood
- Signal Transduction - blood
- Spectrum Analysis, Mass - blood
- Ultraviolet Rays - blood