Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Urban, C; Lackner, H; Sovinz, P; Benesch, M; Schwinger, W; Dornbusch, HJ; Moser, A.
Successful unrelated cord blood transplantation in a 7-year-old boy with Evans syndrome refractory to immunosuppression and double autologous stem cell transplantation.
EUR J HAEMATOL. 2006; 76(6): 526-530.
Doi: 10.1111/j.0902-4441.2006.t01-1-EJH2549.x
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Lackner Herwig
- Urban Ernst-Christian
- Co-Autor*innen der Med Uni Graz
- Benesch Martin
- Dornbusch Hans Jürgen
- Ritter-Sovinz Petra
- Schwinger Wolfgang
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- Abstract:
- Evans syndrome is an autoimmunopathy characterized by thrombocytopenia and autoimmune hemolytic anemia with poor response to immunosuppression. A 2-yr-old boy with Evans syndrome showed only short-lasting responses to immunosuppressive treatment including double autologous peripheral stem cell transplantation (SCT). Intracranial bleeding required emergency splenectomy and external ventricular drainage. Unrelated umbilical cord blood was given following conditioning with busulfan, thiotepa, etoposide and antithymocyte globulin. One year after SCT the patient shows stable blood counts without immunosuppression. This is the first child reported with Evans syndrome successfully treated by means of unrelated cord blood transplantation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenal Cortex Hormones - adverse effects
- Anemia, Hemolytic, Autoimmune - complications
- Cerebral Hemorrhage - etiology
- Child, Preschool - etiology
- Cord Blood Stem Cell Transplantation - etiology
- Danazol - therapeutic use
- Drug Resistance - therapeutic use
- Female - therapeutic use
- Humans - therapeutic use
- Immunoglobulins, Intravenous - therapeutic use
- Immunosuppressive Agents - therapeutic use
- Magnetic Resonance Imaging - therapeutic use
- Male - therapeutic use
- Peripheral Blood Stem Cell Transplantation - therapeutic use
- Purpura, Thrombocytopenic, Idiopathic - complications
- Remission Induction - complications
- Splenectomy - complications
- Transplantation Conditioning - complications
- Transplantation, Autologous - complications
- Transplantation, Homologous - complications
- Vincristine - therapeutic use
- Find related publications in this database (Keywords)
- Evans syndrome
- refractory
- transplantation
- cord blood
- unrelated