Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
von Rahden, BH; Langner, C; Brücher, BL; Stein, HJ; Sarbia, M.
No association of primary adenocarcinomas of the small bowel with Epstein-Barr virus infection.
MOL CARCINOGEN. 2006; 45: 349-352.
Doi: 10.1002/mc.20163
Web of Science
PubMed
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- Langner Cord
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- Abstract:
- Epstein-Barr Virus (EBV) infection is considered to play an etiologic role in human malignancies, including a subset of gastric and cardiac cancers. Adenocarcinomas of the small bowel comprise a very rare entity, with little knowledge about molecular properties and etiological aspects. We have investigated the prevalence of EBER expression (EBV-encoded small RNAs) in a series of small bowel adenocarcinomas (n=56) utilizing RNA in situ hybridization (EBER-RISH). The patients had undergone primary surgical resection at either the Technical University of Munich or at the University of Graz. A surgical series of 82 primary resected gastric (n=36) or cardiac (n=46) adenocarcinomas (TU Munich) was used as control group. None of the 56 small bowel carcinomas exhibited EBER expression whereas in the control group the rate of EBER expression accounted for 4.4% in the group of cardia carcinomas and 8.6% in the group of gastric cancers. These results indicate that EBV infection plays no etiologic role in primary small bowel adenocarcinomas.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - pathology
- Adult - pathology
- Aged - pathology
- Aged, 80 and over - pathology
- Epstein-Barr Virus Infections - pathology
- Female - pathology
- Herpesvirus 4, Human - genetics
- Humans - genetics
- In Situ Hybridization - genetics
- Intestinal Neoplasms - pathology
- Intestine, Small - pathology
- Male - pathology
- Middle Aged - pathology
- RNA, Viral - analysis
- Stomach Neoplasms - pathology
- Find related publications in this database (Keywords)
- Epstein-Barr virus
- EBV
- EBER-RISH
- adenocarcinoma of the small bowel