Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Li, DK; Held, U; Petkau, J; Daumer, M; Barkhof, F; Fazekas, F; Frank, JA; Kappos, L; Miller, DH; Simon, JH; Wolinsky, JS; Filippi, M; Sylvia Lawry Centre for MS Research.
MRI T2 lesion burden in multiple sclerosis: a plateauing relationship with clinical disability.
NEUROLOGY. 2006; 66: 1384-1389.
Doi: 10.1212/01.wnl.0000210506.00078.5c
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Fazekas Franz
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: Previous studies have shown only modest correlation between multiple sclerosis (MS) lesions on MRI and clinical disability. OBJECTIVE: To investigate the relationship between proton density/T2-weighted (T2) burden of disease (BOD) quantitatively measured on MRI scans and clinical determinants including disability. METHODS: Using the Sylvia Lawry Centre for Multiple Sclerosis Research (SLCMSR) database, the authors studied baseline T2 BOD data from a pooled subsample of 1,312 placebo MS patients from 11 randomized controlled trials. Univariate comparisons guided development of multiple regression models incorporating the most important clinical predictors. RESULTS: Significant, although weak to moderate, correlations were found between T2 BOD and age at disease onset, disease duration, disease course, disability (as measured by the Expanded Disability Status Scale [EDSS]), relapse rate, certain presenting symptoms, and gadolinium enhancement. An unexpected but key finding that persisted in the multiple regression analyses was a plateauing relationship between T2 BOD and disability for EDSS values above 4.5. CONCLUSIONS: This study confirmed the limited correlation between clinical manifestations and T2 burden of disease (BOD) but revealed an important plateauing relationship between T2 BOD and disability.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age of Onset -
- Brain - pathology
- Databases, Factual - pathology
- Disability Evaluation - pathology
- Female - pathology
- Humans - pathology
- Magnetic Resonance Imaging - pathology
- Male - pathology
- Multiple Sclerosis - epidemiology
- Randomized Controlled Trials - statistics and numerical data
- Severity of Illness Index - statistics and numerical data