Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Schäfer, E; Weger, M; Birgül, T; Renner, W; Stanger, O; Steinbrugger, I; Schmut, O; Temmel, W; Haas, A.
Angiotensin-converting enzyme insertion/deletion polymorphism and retinal artery occlusion.
Acta Ophthalmol Scand. 2006; 84(3):305-308
Doi: 10.1111/j.1600-0420.2006.00656.x
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- Leading authors Med Uni Graz
- Weger Martin
- Co-authors Med Uni Graz
- Haas Anton
- Renner Wilfried
- Schmut Otto
- Steinbrugger Iris
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- Abstract:
- Purpose: An insertion/deletion (I/D) polymorphism of the gene for angiotensin-converting enzyme (ACE) is associated with higher ACE plasma levels and activity. This enzyme is known to play an important role in blood pressure regulation and the ACE I/D gene polymorphism has been suggested as a risk factor for atherosclerotic vascular diseases. The purpose of the present study was to investigate a hypothesized association between the ACE I/D polymorphism and retinal artery occlusion (RAO). Methods: A total of 159 patients with RAO and 304 control subjects were enrolled in the present retrospective case-control study. ACE I/D genotypes were determined by polymerase chain reaction. Results: Allelic frequencies and genotype distribution of the ACE I/D polymorphism did not significantly differ between patients and control subjects (ACE DD 25.8% versus 28.0%; p = 0.36). A logistic regression analysis predicted the presence of RAO by arterial hypertension and current smoking status, but not by ACE I/D genotypes. Conclusion: Our data suggest that the ACE I/D polymorphism is not a major risk factor for RAO.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Case-Control Studies -
- DNA - genetics
- Female -
- Gene Deletion -
- Gene Frequency -
- Genotype -
- Humans -
- Hypertension - genetics
- Male -
- Mutagenesis, Insertional - genetics
- Peptidyl-Dipeptidase A - genetics
- Polymerase Chain Reaction -
- Polymorphism, Genetic -
- Retinal Artery Occlusion - enzymology Retinal Artery Occlusion - genetics
- Retrospective Studies -
- Risk Factors -
- Smoking - genetics
- Find related publications in this database (Keywords)
- retinal artery occlusion
- angiotensin-converting enzyme
- gene polymorphism
- risk factor