Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reich, O; Regauer, S.
Aromatase expression in low-grade endometrial stromal sarcomas: an immunohistochemical study.
Mod Pathol. 2004; 17(1):104-108
Doi: 10.1038/sj.modpathol.3800031
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- Führende Autor*innen der Med Uni Graz
- Reich Olaf
- Co-Autor*innen der Med Uni Graz
- Regauer Sigrid
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- Abstract:
- Aromatase expression has been described in stromal cells of endometriosis, adenomyosis and endometrial cancer. We analyzed aromatase expression in a series of 23 low-grade endometrial stromal sarcomas. Archival formalin-fixed and paraffin-embedded material was analyzed with immunohistochemistry. Aromatase expression was evaluated with a monoclonal and a polyclonal antibody using the peroxidase-antiperoxidase method. A score was calculated based on the percentage of positive tumor cells and the staining intensity. Aromatase was seen in 19 (83%) of 23 tumors with monoclonal antibody and 20 (87%) of 23 tumors with polyclonal antibody. Aromatase expression using the monoclonal antibody was scored as high in five (22%), moderate in nine (39%) and low in five (22%) tumors. Four (17%) low-grade endometrial stromal sarcomas did not stain for aromatase. Aromatase expression with the polyclonal antibody was scored as high in seven (31%), moderate in four (17%) and low in nine (39%) tumors. Three (13%) low-grade endometrial stromal sarcomas did not stain for aromatase. Little or no aromatase expression tended to correlate with stage I disease, while higher scores were more frequently associated with advanced disease. Our results demonstrate that most low-grade endometrial stromal sarcomas express aromatase. The staining pattern, however, is heterogeneous. The high percentage of aromatase positivity in low-grade endometrial stromal sarcomas may have implications in the management of these tumors and offer new treatment modalities such as hormonal therapy with aromatase inhibitors.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antibodies, Monoclonal -
- Antineoplastic Agents, Hormonal - therapeutic use
- Aromatase - analysis Aromatase - immunology
- Aromatase Inhibitors - therapeutic use
- Endometrial Neoplasms - drug therapy Endometrial Neoplasms - enzymology Endometrial Neoplasms - pathology
- Female -
- Humans -
- Immunoenzyme Techniques -
- Middle Aged -
- Neoplasm Staging -
- Patient Selection -
- Prognosis -
- Sarcoma, Endometrial Stromal - drug therapy Sarcoma, Endometrial Stromal - enzymology Sarcoma, Endometrial Stromal - pathology
- Find related publications in this database (Keywords)
- endometrium
- stromal sarcoma
- aromatase
- treatment