Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ralston, SH; Uitterlinden, AG; Brandi, ML; Balcells, S; Langdahl, BL; Lips, P; Lorenc, R; Obermayer-Pietsch, B; Scollen, S; Bustamante, M; Husted, LB; Carey, AH; Diez-Perez, A; Dunning, AM; Falchetti, A; Karczmarewicz, E; Kruk, M; van Leeuwen, JPTM; van Meurs, JBJ; Mangion, J; McGuigan, FEA; Mellibovsky, L; del Monte, F; Pols, HAP; Reeve, J; Reid, DM; Renner, W; Rivadeneira, F; van Schoor, NM; Sherlock, RE; Ioannidis, JPA.
Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: The GENOMOS study
PLOS MED. 2006; 3: 515-523.
Doi: 10.1371/journal.pmed.0030090
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- Co-Autor*innen der Med Uni Graz
- Obermayer-Pietsch Barbara
- Renner Wilfried
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- Abstract:
- Background Osteoporosis and fracture risk are considered to be under genetic control. Extensive work is being performed to identify the exact genetic variants that determine this risk. Previous work has suggested that a G/T polymorphism affecting an Sp1 binding site in the COLIA1 gene is a genetic marker for low bone mineral density (BMD) and osteoporotic fracture, but there have been no very-large-scale studies of COLIA1 alleles in relation to these phenotypes. Methods and Findings Here we evaluated the role of COLIA1 Sp1 alleles as a predictor of BMD and fracture in a multicenter study involving 20,786 individuals from several European countries. At the femoral neck, the average (95% confidence interval [CI]) BMD values were 25 mg/cm(2) (CI, 16 to 34 mg/cm(2)) lower in TT homozygotes than the other genotype groups (p < 0.001), and a similar difference was observed at the lumbar spine; 21 mg/cm(2) (CI, 1 to 42 mg/cm(2)), (p = 0.039). These associations were unaltered after adjustment for potential confounding factors. There was no association with fracture overall (odds ratio [OR] = 1.01 [CI, 0.95 to 1.08]) in either unadjusted or adjusted analyses, but there was a non-significant trend for association with vertebral fracture and a nominally significant association with incident vertebral fractures in females (OR = 1.33 [CI, 1.00 to 1.77]) that was independent of BMD, and unaltered in adjusted analyses. Conclusions Allowing for the inevitable heterogeneity between participating teams, this study-which to our knowledge is the largest ever performed in the field of osteoporosis genetics for a single gene-demonstrates that the COLIA1 Sp1 polymorphism is associated with reduced BMD and could predispose to incident vertebral fractures in women, independent of BMD. The associations we observed were modest however, demonstrating the importance of conducting studies that are adequately powered to detect and quantify the effects of common genetic variants on complex diseases.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Bone Density -
- Case-Control Studies -
- Collagen Type I - genetics
- Female -
- Genetic Predisposition to Disease -
- Genotype -
- Humans -
- Male -
- Middle Aged -
- Osteoporosis - drug therapy Osteoporosis - genetics
- Polymorphism, Genetic -
- Risk Factors -
- Spinal Fractures - etiology Spinal Fractures - genetics