Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Markert, E; Gruber-Moesenbacher, U; Porubsky, C; Popper, HH.
Lung osteoma--a new benign lung lesion.
Virchows Arch. 2006; 449(1):117-120
Doi: 10.1007/s00428-006-0205-6
(- Case Report)
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Popper Helmuth
- Co-Autor*innen der Med Uni Graz
- Porubsky Christian
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- Abstract:
- Extraskeletal osteomas have not been described in the lung. Tumors with osseous elements can be found, such as hamartoma and amyloid tumor, and reactive lesions such as osseous metaplasia. A 39-year-old male patient was treated for multiple myeloma and got a bone marrow transplantation 2 years and a few months before he presented with a solitary well-circumscribed tumor in the right middle lobe. The patient underwent surgical resection. The tumor presented with a fibrous capsule and consisted of mature bone trabecules. Within the tumor, fatty tissue was seen. There were small bone spicules interpreted as areas of new bone formation and appositional growth. No amyloid deposition, no immature epithelial tubules as in hamartomas, and no normal lung structure as in osseous metaplasia were seen. Within the osseous elements, a positive reaction was seen with antibodies for osteonectin, whereas the reaction for calcitonin was negative. To the best of our knowledge, this is the first case of an osteoma being reported in the lung looking like any other extraskeletal osteoma. This tumor might have been induced by circulating stem cells; however, due to autologous bona marrow transplantation, this cannot be proven.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Bone Marrow Transplantation -
- Bone Neoplasms - chemistry Bone Neoplasms - pathology Bone Neoplasms - surgery
- Diagnosis, Differential -
- Hamartoma - diagnosis
- Humans -
- Immunohistochemistry -
- Lung Neoplasms - chemistry Lung Neoplasms - pathology Lung Neoplasms - surgery
- Male -
- Multiple Myeloma - pathology Multiple Myeloma - therapy
- Neoplasms, Second Primary - chemistry Neoplasms, Second Primary - pathology Neoplasms, Second Primary - surgery
- Ossification, Heterotopic - pathology
- Osteoma - chemistry Osteoma - pathology Osteoma - surgery
- Osteonectin - analysis
- Tumor Markers, Biological - analysis
- Find related publications in this database (Keywords)
- pulmonary osteoma
- hamartoma
- ossification
- osteonectin