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SHR Neuro Cancer Cardio Lipid Metab Microb
Prettenhofer, U; Haas, A; Mayer, R; Stranzl, H; Oechs, A; Hackl, A.
Long-term results after external radiotherapy in age-related macular degeneration. A prospective study.
STRAHLENTHER ONKOL. 2004; 180(2): 91-95.
Doi: 10.1007/s00066-004-1177-6
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Prettenhofer Ulrike
- Co-authors Med Uni Graz
- Haas Anton
- Hackl Arnulf
- Mayer Ramona
- Stranzl-Lawatsch Heidi
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- Abstract:
- Purpose: To prospectively evaluate the short- and Long-term efficacy of external radiotherapy (RT) in patients with age-related macular degeneration (AMD) by comparing two different dose schedules.Patients and Methods: In this prospective, nonrandomized, comparative study including 80 patients, the efficacy of external RT with a total dose of 14.4 Gy (group A, n = 40) and 25.2 Gy (group B, n = 40) was compared. Patients of group A were irradiated between September 1995 and July 1996, patients of group B between August 1996 and November 1997. 67 patients presented with occult choroidal neovascularization (CNV), 13 with classic subfoveal Lesions. Complete ophthalmologic investigation was performed before RT, at intervals of 3 months during the 1st year after RT, and of 6 months thereafter.Results: 12 months after RT, vision deteriorated in 85% (14.4 Gy) and 65% (25.2 Gy) of patients. Central, visual field decreased with both dose schedules. There was no morphological benefit in neovascular changes. After 48 months, complete follow-up was possible in 46 patients who showed a significant toss of vision similar to the natural course of AMD.Conclusion: External RT of AMD with 14.4 Gy as well as with the escalated dose of 25.2 Gy showed a poor beneficial outcome after 6 and 12 months, respectively. After a follow-up of 4 years, visual outcome in irradiated patients was similar to the natural course of the disease. A conspicuous efficacy of RT in prevention of blindness could not be demonstrated.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Choroidal Neovascularization - radiotherapy
- Female -
- Follow-Up Studies -
- Humans -
- Macular Degeneration - radiotherapy
- Male -
- Middle Aged -
- Outcome and Process Assessment (Health Care) -
- Prospective Studies -
- Radiotherapy Dosage -
- Visual Acuity - radiation effects
- Visual Fields - radiation effects
- Find related publications in this database (Keywords)
- age-related macular degeneration
- external radiotherapy
- prospective study
- long-term results