Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Feichtinger, M; Wiendl, H; Körner, E; Holl, A; Gruber, L; Fazekas, F; Schröttner, O; Eder, H; Ott, E.
No effect of immunomodulatory therapy in focal epilepsy with positive glutamate receptor type 3--antibodies.
SEIZURE-EUR J EPILEP. 2006; 15(5): 350-354.
Doi: 10.1016/j.seizure.2006.03.002
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- Führende Autor*innen der Med Uni Graz
- Feichtinger Michael
- Co-Autor*innen der Med Uni Graz
- Eder Hans
- Fazekas Franz
- Gruber-Cichocki Lucia
- Holl Alexander
- Koerner Eva
- Ott Erwin
- Schroettner Oskar
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- Abstract:
- Antibodies against the glutamate receptor type 3-(GluR3) have been found in association with Rasmussen's encephalitis (RE) but were also detected in patients with non-inflammatory focal epilepsies. We report the case of an 18-year-old patient with treatment refractory left mesial temporal lobe epilepsy accompanied by high levels of GluR3 antibodies. Different from experiences in patients with RE immunomodulatory therapy by use of intravenous gammaglobulines neither altered GluR3 serum levels nor had any effect on seizure frequency in our patient. Interestingly, GluR3 serum levels remained positive after successful surgical intervention leading to patient's seizure freedom.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Anterior Temporal Lobectomy -
- Autoantibodies - blood
- Epilepsy, Temporal Lobe - drug therapy
- Humans - drug therapy
- Immunoglobulin G - blood
- Immunoglobulins, Intravenous - therapeutic use
- Immunologic Factors - therapeutic use
- Male - therapeutic use
- Receptors, AMPA - immunology
- Find related publications in this database (Keywords)
- glutamate receptor type 3-antibodies
- immunomodulative therapy
- intravenous gammaglubulines
- focal epilepsy