Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Ferrara, G; Argenziano, G; Soyer, HP; Corona, R; Sera, F; Brunetti, B; Cerroni, L; Chimenti, S; El Shabrawi-Caelen, L; Ferrari, A; Hofmann-Wellenhof, R; Kaddu, S; Piccolo, D; Scalvenzi, M; Staibano, S; Wolf, IH; De Rosa, G.
Dermoscopic and histopathologic diagnosis of equivocal melanocytic skin lesions: an interdisciplinary study on 107 cases.
Cancer. 2002; 95(5):1094-1100
Doi: 10.1002/cncr.10768
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- Führende Autor*innen der Med Uni Graz
- Soyer Hans Peter
- Co-Autor*innen der Med Uni Graz
- Cerroni Lorenzo
- El-Shabrawi-Caelen Laila
- Hofmann-Wellenhof Rainer
- Kaddu Steven
- Wolf Ingrid
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- Abstract:
- Dermoscopy (dermatoscopy, epiluminescence microscopy) is increasingly employed for the preoperative detection of cutaneous melanoma; dermoscopic features of pigmented skin lesions have been previously defined using histopathology as the key to the code. In a preliminary study on 10 cases evaluated by nine dermoscopists and nine histopathologists, the authors experienced that when at least two dermoscopists disagree in evaluating a melanocytic lesion, even histopathologic consultations may give equivocal results. One hundred seven melanocytic skin lesions, consecutively excised because of equivocal clinical and/or dermoscopic features, were retrospectively examined by eight dermoscopists and eight histopathologists; the diagnostic interobserver agreement was calculated by means of the Schouten k statistics. After histopathologic consultations, all 107 lesions underwent unblinded dermoscopic re-evaluation in order to find which dermoscopic features had given rise to histopathologic diagnostic difficulties. The interobserver ageement was good for both dermoscopy (k = 0.53) and histopathology (k = 0.74). Out of 48 cases evaluated by the dermoscopists in complete accordance, only 8 (16.7%) received at least one conflicting histopathologic diagnosis. Instead, among the remaining 59 cases with at least one disagreeing dermoscopic diagnosis, 21 (35.6%) received at least one disagreeing histopathologic diagnosis. The unblinded dermoscopic re-evaluation showed that five out of seven lesions with clear-cut regression structures were histopathologically controversial. At least for selected and reasonably difficult lesions, a diagnostic discrepancy among formally trained dermoscopists seems to be predictive for a diagnostic disagreement among histopathologists. Lesions showing clear-cut regression structures are prone to give some histopathologic disagreement. Copyright 2002 American Cancer Society.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Child -
- Cytodiagnosis - methods
- Diagnosis, Differential -
- Female -
- Humans -
- Male -
- Melanoma - diagnosis Melanoma - pathology
- Microscopy -
- Middle Aged -
- Observer Variation -
- Professional Competence -
- Retrospective Studies -
- Sensitivity and Specificity -
- Skin Neoplasms - diagnosis Skin Neoplasms - pathology
- Find related publications in this database (Keywords)
- dermoscopy
- dermatoscopy
- epiluminescence microscopy
- histopathology
- melanoma
- melanocytic skin lesions
- diagnosis
- interobserver agreement