Medizinische Universität Graz - Research portal
Selected Publication:
Smolle, J; Pfaffenthaler, E; Aberer, W.
Risk factors for adverse cutaneous drug reactions in the therapy of erysipelas. An analytical epidemiological study
ALLERGOLOGIE 1999 22: 467-471.
Web of Science
- Leading authors Med Uni Graz
- Smolle Josef
- Co-authors Med Uni Graz
- Aberer Werner
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- Abstract:
- Antibiotic therapy of erysipelas is often complicated by adverse cutaneous drug reactions. In the present study we examined whether cutaneous drug eruptions are more common in patients treated with penicillin than in those treated with other antibiotics, and whether certain risk factors for the development of a cutaneous drug eruption can be identified in patients treated with penicillin. In a retrospective analysis of 993 in-patients treated for erysipelas, 70 had developed a cutaneous drug eruption. Drug eruptions were significantly more common in patients treated with penicillin than in other patients (relative risk ratio 10.4, 95% confidence interval 1.4 - 75.6). In patients treated with penicillin, laboratory parameters indicating severe inflammation, local complications of the erysipelas and the additional administration of flucloxacillin or non-steroidal antiphlogistic drugs were associated with an increased risk of a cutaneous drug eruption. Our findings suggest that in patients with severe and complicated erysipelas antibiotic therapy other than penicillin should be considered. Furthermore, the additional administration of flucloxacillin and of non-steroidal antiphlogistics should be avoided.
- Find related publications in this database (Keywords)
- erysipelas
- exanthema
- cutaneous drug reaction
- beta-lactam antibiotic
- penicillin
- nonsteroidal antiphlogistic drugs