Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Rieger-Ziegler, V; Kranke, B; Aberer, W.
Comparison of validity of in-vitro testing, skin test and oral provocation in patients with hypersensitivity to acetylsalicylic acid
ALLERGOLOGIE 1999 22: 645-649.
Web of Science

Co-Autor*innen der Med Uni Graz: Aberer Werner; Kränke Birger
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Abstract:: The investigation of hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAID) is of considerable importance in allergological practice. The aim of this study was to investigate the validity of in-vitro testing, skin test and oral provocation in patients with a history of intolerance to acetylsalicylic acid (ASS). 47 patients were included in the study; 32 patients had an anaphylactoid reaction grade I (according to Ring & Messmer), 10 patients a grade II anaphylactoid reaction, and 5 patients a maculopapular rash after intake of ASS. In all 47 patients, serum was investigated for IgE antibodies (RAST) against ASS (Hytec automated EIA system; Hycor Biomedical). 35 patients agreed to hospitalisation for skin testing and oral provocation. Only 5 out of 25 patients with a history of grade I anaphylactoid reaction showed a positive skin test, one of these 5 patients showed a positive oral provocation. 5 out of 20 patients with a negative skin test were found positive in oral provocation. 1 out of 6 patients with grade II anaphylactoid reaction showed a positive skin rest and a positive oral provocation. None of the 5 patients with a maculopapular rash showed a positive skin test or oral provocation. Specific IgE antibodies to ASS could be demonstrated in none of the 47 patients. We conclude that the diagnosis of intolerance to ASS should be based on careful study of the patients' history and in doubtful cases may be supported by oral provocation under adequate safety precautions. In vitro testing for IgE antibodies specific to ASS is not useful.
Find related publications in this database (Keywords): hypersensitivity reactions; NSAIDs; specific IgE-antibodies; diagnosis; RAST