Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Grims, RH; Kränke, B; Aberer, W.
Pitfalls in drug allergy skin testing: false-positive reactions due to (hidden) additives.
CONTACT DERMATITIS. 2006; 54: 290-294.
Doi: 10.1111/j.0105-1873.2006.00835.x
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Grims Robert Hermann
- Co-Autor*innen der Med Uni Graz
- Aberer Werner
- Kränke Birger
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- Abstract:
- Skin testing for drug hypersensitivity is a valuable diagnostic tool and a well established procedure for betalactams and corticosteroids. Although appropriate patch, prick or intracutaneous testing usually permits unequivocal interpretation, the possibility of false-positive reactions must be kept in mind. We report two patients, one with a suspected penicillin allergy and one with a suspected steroid allergy, in whom positive skin tests initially yielded a false diagnosis. In both cases, other findings were inconsistent with the positive skin tests. Therefore, further investigations were performed. After the test preparations had been analysed, the skin test was extended to include the additives, which then yielded the diagnosis of sensitization to the surfactant polysorbate 80 (PS 80, contained in the penicillin test solution) and the emulsion stabilizer carboxymethylcellulose (CMC, contained in the steroid preparation), respectively. It should be noted that positive reactions to test solution additives, as in the first case, may lead to a lifelong false diagnosis of (penicillin) allergy, whereas an undiagnosed allergy to additives in parenteral applications, as in the second case, might prove fatal.
- Find related publications in this database (using NLM MeSH Indexing)
- Allergens - adverse effects
- Dermatitis, Allergic Contact - diagnosis
- Diagnosis, Differential - diagnosis
- False Positive Reactions - diagnosis
- Female - diagnosis
- Humans - diagnosis
- Middle Aged - diagnosis
- Skin Tests - diagnosis
- Find related publications in this database (Keywords)
- additives
- allergy
- carboxymethyl cellulose
- drug eruption
- polysorbate 80
- skin testing
- systemic