Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Komericki, P; Arbab, E; Grims, R; Kränke, B; Aberer, W.
Tryptase as severity marker in drug provocation tests.
INT ARCH ALLERGY IMMUNOL. 2006; 140: 164-169.
Doi: 10.1159/000092556
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Komericki Peter
- Co-Autor*innen der Med Uni Graz
- Aberer Werner
- Arbab Emad
- Grims Robert Hermann
- Kränke Birger
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: In the absence of objective symptoms, it is difficult to assess an adverse reaction during drug provocation testing. We evaluated the value of serum tryptase levels to distinguish between positive, negative and, even more important, so-called 'hysterical' reactions (conversion symptoms). The latter are occasionally observed in drug provocation tests when the patient experiences ambiguous subjective symptoms. METHODS: In a prospective single-center study, 303 patients underwent 785 drug provocation tests. Blood was taken for tryptase measurement on each test day before and after drug challenge, and the changes in serum tryptase levels in patients with no reactions were compared with those who experienced immediate reactions to a drug. RESULTS: Thirty-four of 785 drug provocations were clinically judged as being positive. Despite objective symptoms, median serum tryptase values in the afternoon were even lower than baseline levels. However, this decrease was not statistically significant. In the 751 patients suffering no objective reactions, the median values of post-testing tryptase values were statistically significantly decreased as compared with pretesting values. CONCLUSIONS: The measurement of serum tryptase levels does not appear to be helpful to differentiate mild allergic or nonallergic reactions from 'hysterical' ones. The milder decrease in the group with objective drug reactions might indicate slight mast cell activation in some patients. More severe clinical drug reactions led to stronger mast cell degranulation. Mild reactions did not increase the tryptase levels consistently.
- Find related publications in this database (using NLM MeSH Indexing)
- Acetaminophen - adverse effects
- Adolescent - adverse effects
- Adult - adverse effects
- Aspirin - adverse effects
- Diclofenac - adverse effects
- Drug Hypersensitivity - diagnosis
- Female - diagnosis
- Humans - diagnosis
- Lidocaine - adverse effects
- Male - adverse effects
- Mefenamic Acid - adverse effects
- Middle Aged - adverse effects
- Ofloxacin - adverse effects
- Penicillins - adverse effects
- Prospective Studies - adverse effects
- Serine Endopeptidases - blood
- Find related publications in this database (Keywords)
- drug allergy
- drug provocation test
- mast cell degranulation
- tryptase