Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Benesch, M; Lackner, H; Sovinz, P; Suppan, E; Schwinger, W; Eder, HG; Dornbusch, HJ; Moser, A; Triebl-Roth, K; Urban, C.
Late sequela after treatment of childhood low-grade gliomas: a retrospective analysis of 69 long-term survivors treated between 1983 and 2003.
J Neurooncol. 2006; 78(2):199-205
Doi: 10.1007/s11060-005-9091-z
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- Führende Autor*innen der Med Uni Graz
- Benesch Martin
- Co-Autor*innen der Med Uni Graz
- Dornbusch Hans Jürgen
- Eder Hans
- Lackner Herwig
- Nebl Andrea Maria
- Ritter-Sovinz Petra
- Schwinger Wolfgang
- Urban Ernst-Christian
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- Abstract:
- The aim of the present study was to evaluate the spectrum of late effects in a large cohort of pediatric patients with low-grade gliomas (WHO grade I and II) during an observation period of 20 years. Eighty-seven patients with low-grade gliomas grouped according to tumor location (cerebellum: n=28; cerebral hemispheres: n=21; central midline: n=15; brainstem: n=12; tectum: n=5; other locations: n=6) were evaluated for tumor- and/or treatment-related late effects by analysis of medical and computer records, and personal interviews. Seventy patients underwent neurosurgery, 29 patients received additional radiotherapy and 20 additional chemotherapy. Median follow-up of survivors is 96 months with an overall survival of 79% (cerebellum: 89%; cerebral hemispheres: 95%; central midline: 80%; brainstem: 25%; tectum: 100%; other locations: 66%). Chronic medical problems (mild ataxia to multiple severe neuroendocrine deficits) are observed in 100% of patients with brainstem/central midline tumors and in 40-50% of patients with low-grade gliomas of other locations. Endocrine deficiencies were observed in 15/17 (88%) of long-term survivors who received radiotherapy. In contrast, none of the patients who underwent surgery only had endocrine deficiencies. Seven long-term survivors (10.1%) are severely disabled with permanent need of medical help. Tumor- and treatment-related late effects are common in patients with low-grade gliomas with the most severe occurring in patients with brainstem or central midline tumors. As long-term survival is excellent in patients with low-grade gliomas except for tumors located in the brainstem, future treatment studies should focus on avoiding long-term late effects.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Antineoplastic Agents - adverse effects
- Antineoplastic Agents - epidemiology
- Brain Neoplasms - complications Brain Neoplasms - therapy
- Child -
- Child, Preschool -
- Cohort Studies -
- Combined Modality Therapy - adverse effects
- Disease-Free Survival -
- Endocrine System Diseases - epidemiology Endocrine System Diseases - etiology
- Female -
- Follow-Up Studies -
- Glioma - complications Glioma - therapy
- Hearing Disorders - epidemiology Hearing Disorders - etiology
- Humans -
- Infant -
- Male -
- Nervous System Diseases - epidemiology Nervous System Diseases - etiology
- Radiation Injuries - epidemiology
- Retrospective Studies -
- Survivors - statistics & numerical data
- Vision Disorders - epidemiology Vision Disorders - etiology
- Find related publications in this database (Keywords)
- children
- late effects
- low-grade gliomas
- outcome
- treatment