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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Egger, G; Aigner, R; Glasner, A; Hofer, HP; Mitterhammer, H; Zelzer, S.
Blood polymorphonuclear leukocyte migration as a predictive marker for infections in severe trauma: comparison with various inflammation parameters.
INTENS CARE MED. 2004; 30: 331-334.
Doi: 10.1007/s00134-003-2111-6
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Egger Gerd
- Co-authors Med Uni Graz
- Aigner Reingard
- Hofer Herwig
- Mitterhammer Heike
- Zelzer Sieglinde
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- Abstract:
- OBJECTIVE: To assess in patients with multiple trauma the relevance of the following as predictive markers for infections: the inflammation parameters white blood count, body temperature, blood polymorphonuclear leukocyte (PMN) migration; blood levels of C-reactive protein, PMN elastase, procalcitonin, neopterin, interleukin 6, interleukin 8, malondialdehyde, total antioxidative status; the stress parameters cortisol and lactate. DESIGN: Prospective observational cohort study. SETTING: Intensive Care Unit of a university surgical department. PATIENTS: Twenty-six patients with multiple trauma of differing severity. MEASUREMENTS AND RESULTS: Trauma severity was estimated by the ISS. PMN migration upon F-Met-Leu-Phe stimulation was determined in fresh whole blood in a ready-for-use, one-way membrane filter assay and evaluated by automated image analysis. The other parameters were measured with commercially available tests. During hospitalization, nine patients developed infections, and 17 patients were free of infection. PMN migration below a critical minimum preceded infections in eight of the infected, but occurred in only three of the non-infected patients (positive/negative predictive values 0.72/0.93; sensitivity/specificity 0.88/0.82; likelihood ratio 5.0). Fever (> or =38.0 degrees C) had predictive values of 0.83/0.80 and a high likelihood ratio of 9.4, but a low sensitivity/specificity of 0.55/0.94. The other parameters were without significance. Procalcitonin, elastase, C-reactive protein, neopterin and lactate correlated positively with the injury severity score. CONCLUSION: PMN migration proved to be a highly sensitive predictive marker for infections. The whole-blood PMN migration test may facilitate early aggressive antimicrobial therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Biological Markers - blood
- C-Reactive Protein - analysis
- Calcitonin - blood
- Cell Movement - blood
- Cohort Studies - blood
- Humans - blood
- Infection - blood
- Interleukin-1 - blood
- Interleukin-8 - blood
- Leukocyte Count - blood
- Neutrophils - cytology
- Predictive Value of Tests - cytology
- Prospective Studies - cytology
- Protein Precursors - blood
- Wounds and Injuries - complications
- Find related publications in this database (Keywords)
- PMN
- migration
- trauma
- nfection
- predictive
- marker