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Morton, C; Horn, M; Leman, J; Tack, B; Bedane, C; Tjioe, M; Ibbotson, S; Khemis, A; Wolf, P.
Comparison of topical methyl aminolevulinate photodynamic therapy with cryotherapy or Fluorouracil for treatment of squamous cell carcinoma in situ: Results of a multicenter randomized trial.
Arch Dermatol. 2006; 142(6):729-735 Doi: 10.1001/archderm.142.6.729 [OPEN ACCESS]
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Co-authors Med Uni Graz: Horn Michael; Wolf Peter
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Abstract:: Objective: To compare the efficacy, tolerability, and cosmetic outcome of photodynamic therapy (PDT) using topical methyl aminolevulinate with cryotherapy or topical fluorouracil for treatment of squamous cell carcinoma in situ. Design: Randomized, placebo-controlled study, with follow-up at 3 and 12 months after last treatment. Setting: Forty outpatient dermatology centers in 11 European countries. Patients: Random sample of 225 patients with histologically confirmed squamous cell carcinoma in situ (lesion size, 6-40 mm) and no evidence of progression. Interventions: Treatment with PDT with methyl aminolevulinate (160 mg/g; n=96) or matching placebo cream (n=17), cryotherapy (n=82), or topical fluorouracil (5% cream; n = 30). Methyl aminolevulinate or placebo cream was applied for 3 hours before illumination with broadband red light (75 J/cm(2), 570-670 nm). Treatment was repeated 1 week later. Cryotherapy was performed with liquid nitrogen spray. Fluorouracil was applied for 4 weeks. Lesions with a partial response at 3 months were re-treated. Main Outcome Measures: Clinically verified complete response of lesions; blinded and on-site assessment of cosmetic outcome (4-point rating scale). Results: At 12 months, the estimated sustained lesion complete response rate with methyl ammolevulinate PDT was superior to that with cryotherapy (80% vs 67%; odds ratio, 1.77; 95% confidence interval, 1.01-3.12; P=.047), and better than that with fluorouracil (80% vs 69%; odds ratio, 1.64; 95% confidence interval, 0.78-3.45; P=. 19). Cosmetic outcome at 3 months was good or excellent in 94% of patients treated with methyl aminolevulinate PDT vs 66% with cryotherapy and 76% with fluorouracil, and was maintained at 12 months. Conclusion: Methyl aminolevulinate PDT is an effective treatment option for squamous cell carcinoma in situ, with excellent cosmesis.
Find related publications in this database (using NLM MeSH Indexing): Administration, Cutaneous -; Adult -; Aged -; Aged, 80 and over -; Aminolevulinic Acid - administration & dosage; Antimetabolites, Antineoplastic - administration & dosage; Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery; Cryotherapy -; Double-Blind Method -; Double-Blind Method -; Female -; Fluorouracil - administration & dosage; Humans -; Male -; Middle Aged -; Photochemotherapy -; Photosensitizing Agents - administration & dosage; Skin Neoplasms - drug therapy Skin Neoplasms - pathology Skin Neoplasms - surgery; Treatment Outcome -