Medizinische Universität Graz - Research portal
Selected Publication:
Knauer, A; Sirichaisinthop, J; Reinthaler, FF; Wiedermann, G; Wernsdorfer, G; Wernsdorfer, WH.
In-vitro response of Plasmodium falciparum to the main alkaloids of Cinchona in northwestern Thailand.
Wien Klin Wochenschr. 2003; 115 Suppl 3(19-20 Suppl 4):39-44
Web of Science
PubMed
- Co-authors Med Uni Graz
- Reinthaler Franz
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Abstract:
- The blood schizontocidal activity of the four main Cinchona alkaloids against Plasmodium falciparum was compared in 46 fresh parasite isolates, using an in-vitro test measuring the drug-specific inhibition of schizont maturation. The studies were conducted in June-August 2001 at Mae Sot, northwestern Thailand, an area where quinine alone is no longer able to eliminate infections with P. falciparum. Quinidine showed the highest blood schizontocidal activity, followed by cinchonine, cinchonidine and finally quinine, which was identified as the least active compound. The isolates showed marked heterogeneity in their response to the Cinchona alkaloids. There was also high correlation of activity among all four alkaloids. The mean EC50 values for quinine, quinidine, cinchonine and cinchonidine were 144 nM, 80 nM, 104 nM and 225 nM, respectively, and the EC99 values 8040 nM, 861 nM, 1176 nM and 6531 nM. The EC99 values for quinine and cinchonidine are beyond the therapeutic concentration range and those for quinidine within it. For cinchonine, values are likely to be within this range, but toxicological and pharmacokinetic studies on this compound are required for clarifying its potential future role in the treatment of falciparum malaria.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Animals -
- Antimalarials - administration and dosage
- Cell Proliferation - drug effects
- Chloroquine - administration and dosage
- Cinchona Alkaloids - administration and dosage
- Dose-Response Relationship, Drug -
- Drug Combinations -
- Drug Evaluation - methods
- Humans -
- Malaria, Falciparum - blood Malaria, Falciparum - drug therapy Malaria, Falciparum - parasitology
- Phytotherapy - methods
- Plant Extracts - administration and dosage
- Plasmodium falciparum - classification Plasmodium falciparum - cytology Plasmodium falciparum - drug effects Plasmodium falciparum - growth and development
- Species Specificity -
- Thailand -
- Find related publications in this database (Keywords)
- Plasmodium falciparum
- drug sensitivity
- in vitro
- Cinchona alkaloids
- Thailand