Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schmidt, R; Enzinger, C; Ropele, S; Schmidt, H; Fazekas, F.
Subcortical vascular cognitive impairment: similarities and differences with multiple sclerosis.
J NEUROL SCI. 2006; 245(1-2): 3-7.
Doi: 10.1016/j.jns.2005.06.018
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- Führende Autor*innen der Med Uni Graz
- Schmidt Reinhold
- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
- Fazekas Franz
- Ropele Stefan
- Schmidt Helena
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- Abstract:
- Subcortical vascular cognitive impairment is caused by lacunes and widespread ischemic white matter damage which closely resembles white matter abnormalities seen in multiple sclerosis. Recent evidence suggests that the progression rate of ischemic white matter lesions on MRI is very similar to that observed in multiple sclerosis. Consequently, it has been proposed to use MRI for monitoring disease activity not only in multiple sclerosis but also in vascular dementia trials. There is first evidence from magnetization transfer imaging studies that other than in MS normal appearing white matter is not affected in cerebral small vessel disease. This contrasts the hypothesis that ischemic white matter damage extends far beyond changes visible on conventional MR. The cognitive consequences of both diseases are strikingly similar which is at least partly caused by damage to frontal-subcortical circuits. Involvement of these common functional anatomical structures and their modulatory transmitter systems has now led to common interventional approaches such as the use of cholinesterase inhibitors.
- Find related publications in this database (using NLM MeSH Indexing)
- Brain Mapping -
- Cognition - physiology
- Dementia, Vascular - diagnosis
- Humans - diagnosis
- Magnetic Resonance Imaging - methods
- Multiple Sclerosis - diagnosis
- Find related publications in this database (Keywords)
- vascular dementia
- cognition
- dementia
- MRI
- white matter lesions
- frontal lobe dysfunction
- cholinesterase inhibitors