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SHR Neuro Cancer Cardio Lipid Metab Microb
Köppel, H; Renner, W; Gugl, A; Cichocki, L; Gasser, R; Wascher, TC; Pilger, E.
The angiotensin-converting-enzyme insertion/deletion polymorphism is not related to venous thrombosis.
Thromb Haemost. 2004; 91(1):76-79
Doi: 10.1267/THRO04010076
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Köppel Herwig
- Co-authors Med Uni Graz
- Gasser Robert
- Pilger Ernst
- Renner Wilfried
- Wascher Thomas
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- Abstract:
- The insertion/deletion (I/D) polymorphism of the gene for angiotensin-converting-enzyme (ACE) is associated with ACE plasma levels and activity. Conflicting results have been reported about the relevance of this polymorphism for venous thrombosis. The aim of the present study was to analyze the role of this polymorphism for deep venous thrombosis. The study was designed as a case-control study, including 330 patients with documented deep venous thrombosis and 354 controls. ACE genotype was determined by size-analysis of polymerase chain reaction products. Results showed that, ACE genotype frequencies were similar between patients (II: 24.8%; ID: 43.3%; DD: 31.8%) and controls (II: 22.9%; ID: 50.6%; DD: 26.6%, P = 0.15).The adjusted odds ratio of carriers of the DD geno-type for venous thrombosis was 1.24 (95% confidence interval 0.90-1.80).The polymorphism was furthermore not associated with age at first thromboembolic event or the occurrence of pulmonary embolism. From these results, we can conclude that the ACE I/D polymorphism is not a significant risk factor for deep venous thrombosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Case-Control Studies -
- Female -
- Gene Deletion -
- Genotype -
- Humans -
- Male -
- Middle Aged -
- Peptidyl-Dipeptidase A - genetics
- Polymorphism, Genetic - genetics
- Risk Factors - genetics
- Venous Thrombosis - genetics
- Find related publications in this database (Keywords)
- angiotensin-converting-enzyme
- polymorphism
- genetics
- venous thromboembolism