Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kadyrov, M; Kingdom, JC; Huppertz, B.
Divergent trophoblast invasion and apoptosis in placental bed spiral arteries from pregnancies complicated by maternal anemia and early-onset preeclampsia/intrauterine growth restriction.
AMER J OBSTET GYNECOL. 2006; 194: 557-563.
Doi: 10.1016/j.ajog.2005.07.035
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Huppertz Berthold
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- Abstract:
- OBJECTIVE: Impaired trophoblast invasion into spiral arteries is associated with early-onset intrauterine growth restriction and preeclampsia. We compared trophoblast invasion into spiral arteries in pregnancies with maternal anemia or early-onset preeclampsia/intrauterine growth restriction and related these findings to trophoblast apoptosis. STUDY DESIGN: Full-thickness uterine wall samples were obtained from women with early-onset preeclampsia/intrauterine growth restriction (n = 6), normal pregnancies (n = 5), and chronic anemia (n = 8). Trophoblast invasion into the walls of spiral arteries was quantified by morphometric analysis of paraffin sections stained with anticytokeratin 18, antiactin, and anticytokeratin 18 neoepitope (M30) antibodies. RESULTS: Trophoblast invasion into spiral arteries was increased in anemic pregnancies (mean [SD]: 206 [46] cell profiles/mm2) and severely impaired in preeclamptic/intrauterine growth restriction pregnancies (17 [6]), compared with normal subjects (149 [52]). Spiral artery lumen area was increased in anemia (0.07 [0.03] mm2) versus normal pregnancies (0.09 [0.04] mm2) and reduced in preeclampsia/intrauterine growth restriction (0.04 [0.02] mm2). Trophoblast apoptosis was similar in anemic (4.2% [3.4%]) and normal (5.0% [1.9%]) pregnancies but increased in preeclampsia/intrauterine growth restriction (12% [5.6%]). CONCLUSION: Trophoblast invasion into the placental bed in early-onset preeclampsia/intrauterine growth restriction is limited by increased apoptosis, resulting in narrower spiral arteries, which is in contrast to findings in anemia.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anemia - pathology
- Apoptosis - pathology
- Arteries - physiopathology
- Comparative Study - physiopathology
- Female - physiopathology
- Fetal Growth Retardation - pathology
- Gestational Age - pathology
- Humans - pathology
- Immunohistochemistry - pathology
- Placenta - blood supply
- Pre-Eclampsia - pathology
- Pregnancy - pathology
- Pregnancy Complications - pathology
- Research Support, Non-U.S. Gov't - pathology
- Trophoblasts - pathology
- Find related publications in this database (Keywords)
- early-onset preeclampsia
- intrauterine growth restriction maternal
- anemia
- intramural/endovascular trophoblast
- apoptosis