Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stranzl, H; Mayer, R; Ofner, P; Peintinger, F; Prettenhofer, U; Hackl, A.
Extracapsular extension in positive axillary lymph nodes in female breast cancer patients. Patterns of failure and indications for postoperative locoregional irradiation.
STRAHLENTHER ONKOL. 2004; 180(1): 31-37.
Doi: 10.1007/s00066-004-1170-0
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Stranzl-Lawatsch Heidi
- Co-Autor*innen der Med Uni Graz
- Hackl Arnulf
- Mayer Ramona
- Ofner-Kopeinig Petra
- Peintinger Florentia
- Prettenhofer Ulrike
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Background and Purpose: There has been little information regarding lymph node-positive breast cancer patients with extracapsular extension (ECE). The aim of this study was to evaluate the rote of ECE in predicting survival and relapse rates.Patients and Methods: From 1994-2002, 1,078 Lymph node-positive women with breast carcinoma were treated at our institution, whereas 301 patients (27.9%) presented with ECE. 91 patients (30.2%) were identified as having three or Less Lymph nodes involved, 27.9% patients four to six, 15.6% patients seven to nine, and 26.2% patients ten or more nodes, respectively. The median age was 58.4 years (range: 28-84 years) and the median follow-up 34 months (range: 2-99 months). Nodal irradiation was given to patients with four or more positive lymph nodes. Chemotherapy was administered to 69.8%, hormonal therapy to 53.2%, and combined systemic treatment to 26% of patients.Results: The 1-, 3-, and 5-year overall survival (OS) was 98%, 84%, and 73%, the 1-, 3-, and 5-year disease-free survival (DFS) 95%, 69%, and 58%, and the 1-, 3-, and 5-year metastasis-free survival (MFS) 96%, 73%, and 60%. The relapse rates were 6.6% (local), 0.3% (supraclavicular), 0.7% (isolated axillary), 1% (local + axillary), and 0.7% (local + supraclavicular), respectively. 81 patients (27%) developed distant metastases. In December 2002, 245 patients (81.4%) were alive, 202/245 without progression, 32/245 with distant metastases, 5/245 with local/locoregional recurrence, and 6/245 patients with local and distant failure.Conclusion: Isolated axillary nodal failure remains low in lymph node-positive patients with ECE. Balancing the risks and benefits of irradiation, we continue to recommend that complete axillary irradiation is not routinely indicated after adequate axillary dissection.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma, Mucinous - drug therapy Adenocarcinoma, Mucinous - mortality Adenocarcinoma, Mucinous - pathology Adenocarcinoma, Mucinous - radiotherapy
- Adult -
- Aged -
- Aged, 80 and over -
- Breast Neoplasms - drug therapy Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - radiotherapy
- Carcinoma, Ductal - drug therapy Carcinoma, Ductal - mortality Carcinoma, Ductal - pathology Carcinoma, Ductal - radiotherapy
- Carcinoma, Lobular - drug therapy Carcinoma, Lobular - mortality Carcinoma, Lobular - pathology Carcinoma, Lobular - radiotherapy
- Chemotherapy, Adjuvant -
- Combined Modality Therapy -
- Disease-Free Survival -
- Follow-Up Studies -
- Humans -
- Lymph Node Excision -
- Lymphatic Irradiation -
- Lymphatic Metastasis - pathology Lymphatic Metastasis - radiotherapy
- Mastectomy, Modified Radical -
- Mastectomy, Segmental -
- Middle Aged -
- Prognosis -
- Radiotherapy, Adjuvant -
- Survival Rate -
- Find related publications in this database (Keywords)
- breast cancer
- node-positive
- extracapsular extension
- relapse