Medizinische Universität Graz - Research portal
Selected Publication:
Steinbrugger, B; Eber, E; Modl, M; Weinhandl, E; Zach, MS.
A comparison of a single-step cold-dry air challenge and a routine histamine provocation for the assessment of bronchial responsiveness in children and adolescents.
CHEST 1995 108: 741-745.
Doi: 10.1378/chest.108.3.741
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Eber Ernst
- Modl Manfred
- Weinhandl Elisabeth
- Zach Maximilian
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- It has remained unclear whether bronchial responsiveness as measured by a single-step cold-dry air challenge (CACh) correlates closely to the responsiveness that is assessed by a routine pharmacologic challenge. On 2 consecutive days, we performed a CACh and a histamine challenge in 128 symptom- and medication-free pediatric and adolescent asthma patients. The CACh consisted of 4 min of isocapnic hyperventilation of -10 degrees C, absolutely dry air; responsiveness was expressed by the induced change in FEV1 (delta FEV1). The histamine challenge consisted of sequential inhalations of incremental increases in concentrations of histamine; responsiveness was expressed by the concentration which caused a 20% fall of FEV1 (PC20). Five children did not bronchoconstrict sufficiently in the histamine challenge for measuring a PC20 and were excluded from analysis. In the remaining 123, delta FEV1 (CACh) ranged from +5 to -73%, PC20 (histamine) from 0.05 to 7.2 mg/mL. There was a statistically significant correlation between delta FEV1 and PC20 (r = 0.54, p < 0.001), but also a considerable scatter of individual data points around the regression line. Fifty-two subjects were hyperresponsive by CACh and 114 by histamine criteria. There is a relatively weak correlation between the results of these two challenges; thus, one cannot be substituted one for the other. Histamine appears as more sensitive in detecting airway hyperresponsiveness than CACh. The poor correlation between the responses to these two challenges can be explained by differences between the challenge protocols, or, alternatively, by differences between applied stimuli and activated mechanisms.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Asthma - diagnosis
- Bronchial Hyperreactivity - physiopathology
- Bronchial Provocation Tests - methods
- Child - methods
- Cold - methods
- Female - methods
- Forced Expiratory Volume - physiology
- Histamine - diagnostic use
- Humans - diagnostic use
- Humidity - diagnostic use
- Male - diagnostic use
- Sensitivity and Specificity - diagnostic use
- Find related publications in this database (Keywords)
- Bronchial Responsiveness
- Cold-Dry Air Challenge
- Histamine Provocation
- Pediatric Asthma