Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Krippl, P; Langsenlehner, U; Renner, W; Yazdani-Biuki, B; Wolf, G; Wascher, TC; Paulweber, B; Bahadori, B; Samonigg, H.
The L10P polymorphism of the transforming growth factor-beta 1 gene is not associated with breast cancer risk.
Cancer Lett. 2003; 201(2):181-184
Doi: 10.1016/S0304-3835(03)00468-3
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- Führende Autor*innen der Med Uni Graz
- Krippl Peter
- Co-Autor*innen der Med Uni Graz
- Langsenlehner Uwe
- Renner Wilfried
- Samonigg Hellmut
- Wascher Thomas
- Yazdani-Biuki Babak
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- Abstract:
- Transforming growth factor-beta 1 (TGF-beta1) is a potent inhibitor of proliferation of epithelial, endothelial and hematopoietic cells and acts as a tumor suppressor. The gene for TGF-beta1, TGFB1, carries a common T/C variation of nucleotide 29, resulting in a leucine (L) to proline (P) polymorphism at codon 10 (TGFB1 L10P). The less common 10P allele has repeatedly been linked to higher TGF-beta1 levels and in at least one study to a lower incidence of breast cancer. To further analyze the role of this polymorphism for breast cancer risk, 500 patients with histologically confirmed breast cancer and 500 sex-and age-matched healthy control subjects were genotyped for the TGFB1 L10P polymorphism by an allele-specific polymerase chain reaction assay. TGFB1 LL, LP and PP genotype frequencies were not significantly different for patients (39.6, 44.2, 16.2%) and controls (36.5, 45.9, 17.6%). We conclude that the TGFB1 L10P polymorphism is not associated with breast cancer risk.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age Distribution -
- Aged -
- Aged, 80 and over -
- Breast Neoplasms - genetics
- Case-Control Studies - genetics
- DNA, Neoplasm - genetics
- Female - genetics
- Genotype - genetics
- Humans - genetics
- Middle Aged - genetics
- Polymorphism, Genetic - genetics
- Risk Factors - genetics
- Transforming Growth Factor beta - genetics
- Transforming Growth Factor beta1 - genetics
- Find related publications in this database (Keywords)
- breast cancer
- transforming growth factor
- gene polymorphism