Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schlede, E; Aberer, W; Fuchs, T; Gerner, I; Lessmann, H; Maurer, T; Rossbacher, R; Stropp, G; Wagner, E; Kayser, D.
Chemical substances and contact allergy--244 substances ranked according to allergenic potency.
Toxicology. 2003; 193(3):219-259
Doi: 10.1016%2FS0300-483X%2803%2900266-X
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- Co-Autor*innen der Med Uni Graz
- Aberer Werner
- Fuchs Ingo
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- Abstract:
- From 1985 to 2001 a group consisting of thirty experts including dermatologists from universities, representatives from the chemical industry and from regulatory authorities elaborated and consequently decided on the potency ranking of chemicals with contact allergenic properties. These chemicals were defined either as synthetic chemicals or as chemicals identified as ingredients in natural products. On 244 substances clinical and experimental data on humans and results of animal tests as documented in the scientific literature were carefully collected and evaluated. This careful evaluation and assessment of these chemicals clearly demonstrate that ranking of substances according to their allergenic potency is possible and justified. It was decided to rank the most potent contact allergens in Category A of substances having significant allergenic properties. Substances with a solid-based indication of a contact allergenic potential and substances with the capacity of cross-reactions were listed in Category B and substances with insignificant or questionable allergenic effects were listed in Category C. An assessment of these compiled data is published here. Three Appendices give a comprehensive overview of the 98 substances listed in Category A, the 77 substances listed in Category B and the 69 substances listed in Category C.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Dermatitis, Allergic Contact -
- Humans -
- Organic Chemicals - adverse effects
- Skin Tests - adverse effects
- Structure-Activity Relationship - adverse effects
- Find related publications in this database (Keywords)
- allergic contact dermatitis
- human and animal data
- potency ranking
- synthetic chemicals
- chemicals identified as ingredients in natural products