Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Ullmann, R; Bongiovanni, M; Halbwedl, I; Fraire, AE; Cagle, PT; Mori, M; Papotti, M; Popper, HH.
Is high-grade adenomatous hyperplasia an early bronchioloalveolar adenocarcinoma?
J Pathol. 2003; 201(3):371-376
Doi: 10.1002/path.1460
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Popper Helmuth
- Co-Autor*innen der Med Uni Graz
- Halbwedl Iris
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- Abstract:
- Atypical adenomatous hyperplasia (AAH) is a probable forerunner of bronchioloalveolar carcinoma (BAC) and pulmonary adenocarcinoma (AC) of mixed type. The present study analysed four low-grade AAHs, 13 high-grade AAHs, two BACs, nine mixed ACs, and one squamous cell carcinoma derived from 13 patients using comparative genomic hybridization. The average number of chromosomal aberrations was 1.2 in low-grade AAH, 9.6 in high-grade AAH, and 12.5 in AC. A high degree of overlap of genetic changes was found in high-grade AAH, BAC, and AC within individual patients. The high number of aberrations and the degree of shared aberrations found in high-grade AAH and AC raises questions about the separation of these two entities. In addition, in view of the monoclonal origin of multiple foci within the same patient, AAH may not be a precursor of AC in some cases, but rather may represent intraepithelial spread.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma, Bronchiolo-Alveolar - genetics
- Adenoma - genetics
- Carcinoma, Squamous Cell - genetics
- Chromosomes, Human, X - genetics
- DNA, Neoplasm - genetics
- Humans - genetics
- Hybridization, Genetic - genetics
- Hyperplasia - pathology
- Lung Neoplasms - genetics
- Neoplasm Invasiveness - genetics
- Polymerase Chain Reaction - methods
- Precancerous Conditions - genetics
- Sex Chromosome Aberrations - genetics
- Find related publications in this database (Keywords)
- atypical adenomatous hyperplasia
- AAH
- bronchioloalveolar carcinoma
- adenocarcinoma
- CGH