Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Winkelmann, BR; Hoffmann, MM; Nauck, M; Kumar, AM; Nandabalan, K; Judson, RS; Boehm, BO; Tall, AR; Ruaño, G; März, W.
Haplotypes of the cholesteryl ester transfer protein gene predict lipid-modifying response to statin therapy.
PHARMACOGENOMICS J. 2003; 3(5): 284-296.
Doi: 10.1038/sj.tpj.6500195
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- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- Cholesteryl ester transfer protein (CETP) plays a central role in high-density lipoprotein (HDL) metabolism. Single nucleotide polymorphisms (SNPs) and haplotypes in the CETP gene were determined in 98 patients with untreated dyslipidemias and analyzed for associations with plasma CETP and plasma lipids before and during statin treatment. Individual CETP SNPs and haplotypes were both significantly associated with CETP enzyme mass and activity. However, only certain CETP haplotypes, but not individual SNPs, significantly predicted the magnitude of change in HDL cholesterol (HDL-C) and triglycerides. After adjusting for covariates and multiple testing, the TTCAAA haplotype showed a gene-dose effect in predicting the HDL-C increase (P=0.03), while the TTCAAAGGG and AAAGGG haplotypes predicted a decrease in triglycerides (P=0.04 both). This is the first study to demonstrate that SNP haplotypes derived from allelic SNP combinations in the CETP gene were more informative than single SNPs in predicting the response to lipid-modifying therapy with statins.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Cardiovascular Diseases - blood
- Carrier Proteins - genetics
- Cholesterol Ester Transfer Proteins - genetics
- Cohort Studies - genetics
- Female - genetics
- Glycoproteins - genetics
- Haplotypes - genetics
- Humans - genetics
- Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
- Lipids - blood
- Male - blood
- Middle Aged - blood
- Predictive Value of Tests - blood
- Variation (Genetics) - genetics
- Find related publications in this database (Keywords)
- cholesteryl ester transfer protein
- HDL-cholesterol
- triglycerides
- haplotype
- single nucleotide polymorphism
- statin