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Selected Publication:
Wolf, P; Hoffmann, C; Quehenberger, F; Grinschgl, S; Kerl, H.
Immune protection factors of chemical sunscreens measured in the local contact hypersensitivity model in humans.
J Invest Dermatol. 2003; 121(5):1080-1087
Doi: 10.1046/j.1523-1747.2003.12361.x
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- Leading authors Med Uni Graz
- Wolf Peter
- Co-authors Med Uni Graz
- Kerl Helmut
- Quehenberger Franz
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- Abstract:
- We conducted a randomized trial designed to calculate human in vivo immune protection factors of two sunscreen preparations in a model of ultraviolet-induced local suppression of the induction of contact hypersensitivity to 2,4-dinitrochlorobenzene. Seventy-five male subjects were exposed in a multistage study to multiples of their individual minimal erythema dose of solar-simulated ultraviolet radiation with or without protection by an ultraviolet B sunscreen (sun protection factor 5.2) or a broad-spectrum ultraviolet A + B sunscreen (sun protection factor 6.2). After 24 h subjects were sensitized with 50 microL of 0.0625% 2,4-dinitrochlorobenzene on a nonirradiated or ultraviolet-irradiated field on the buttock that was unprotected or protected by sunscreen. Three weeks after sensitization the subjects were challenged with varying concentrations of 2,4-dinitrochlorobenzene on their upper inner arm, and the contact hypersensitivity response was determined at 48 and 72 h based on a semiquantitative clinical score, contact hypersensitivity lesion diameters, and dermal skin edema measurement by 20 MHz ultrasound. The 50% immunosuppressive dose ranged from 0.63 to 0.79 minimal erythema dose, depending on the endpoint parameter. Both sunscreens offered significant immunoprotection (p = 0.014-0.002) and their immune protection factor ranged from 4.5 to 5.8 (ultraviolet B sunscreen) and from 7.7 to 11 (ultraviolet A + B sunscreen). The immune protection factor of the ultraviolet B sunscreen was similar to the sun protection factor (5.2), whereas the sunscreen with broad-spectrum ultraviolet A + B protection exhibited better immunoprotective capacity than predicted from the sun protection factor.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Dermatitis, Contact - immunology
- Female - immunology
- Humans - immunology
- Immune Tolerance - drug effects
- Male - drug effects
- Middle Aged - drug effects
- Neoplasms, Radiation-Induced - etiology
- Skin Neoplasms - etiology
- Sunscreening Agents - pharmacology
- Ultraviolet Rays - adverse effects
- Find related publications in this database (Keywords)
- immune suppression
- skin cancer
- solar simulated UV radiation
- suberythemal effect
- sun protection factor