Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Benesch, M; Kerbl, R; Lackner, H; Berghold, A; Schwinger, W; Triebl-Roth, K; Urban, C.
Low-dose versus high-dose immunoglobulin for primary treatment of acute immune thrombocytopenic purpura in children: results of a prospective, randomized single-center trial.
J Pediatr Hematol Oncol. 2003; 25(10):797-800
Doi: 10.1097%2F00043426-200310000-00011
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- Führende Autor*innen der Med Uni Graz
- Benesch Martin
- Co-Autor*innen der Med Uni Graz
- Berghold Andrea
- Kerbl Reinhold
- Lackner Herwig
- Schwinger Wolfgang
- Urban Ernst-Christian
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- Abstract:
- PURPOSE: To investigate the efficacy and side effects of two different intravenous immunoglobulin (IVIG) dose regimens for the initial treatment of childhood acute immune thrombocytopenic purpura (ITP). METHODS: Thirty-four consecutive patients with a clinical diagnosis of acute ITP and a platelet count below 20x10(9)/L were randomized to receive either 1 g/kg body weight (n=17; group A) or 0.3 g/kg body weight (n=17; group B) IVIG per day for 2 consecutive days (total dose 2 g/kg and 0.6 g/kg). RESULTS: Fifteen of the 17 patients (88.2%) in group A and 13 of the 17 patients (76.5%) in group B achieved a platelet count of more than 20x10(9)/L within 72 hours. The increase in platelet counts on day 2 and 3 was more pronounced in the high-dose group. Two patients in the high-dose group and four in the low-dose group were non-responders. Chronic disease occurred in three patients receiving 2 g/kg IVIG and in five patients receiving 0.6 g/kg IVIG. Side effects of IVIG administration were more common in the high-dose group. CONCLUSIONS: The present study showed that platelet counts increased more rapidly after high-dose IVIG administration within the first 72 hours, although a platelet count of more than 20x10(9)/L can be achieved also with low-dose IVIG in most children with acute ITP. For patients with very low platelet counts, doses higher than 0.6 g/kg seem, therefore, to be more effective.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Adolescent -
- Blood Platelets - cytology
- Child - cytology
- Child, Preschool - cytology
- Chronic Disease - cytology
- Dose-Response Relationship, Drug - cytology
- Female - cytology
- Humans - cytology
- Immunoglobulins, Intravenous - administration and dosage
- Immunotherapy - administration and dosage
- Infant - administration and dosage
- Male - administration and dosage
- Platelet Count - administration and dosage
- Purpura, Thrombocytopenic, Idiopathic - drug therapy
- Random Allocation - drug therapy
- Recurrence - drug therapy
- Find related publications in this database (Keywords)
- acute immune thrombocytopenic purpura childhood
- IVIG