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Eber, E; Varga, EM; Zach, MS.
Cold air challenge of airway reactivity in children: a correlation of transcutaneously measured oxygen tension and conventional lung functions.
PEDIAT PULM 1991 10: 273-277. Doi: 10.1002/ppul.1950100409
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Leading authors Med Uni Graz: Eber Ernst
Co-authors Med Uni Graz: Varga Eva-Maria; Zach Maximilian
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Abstract:: For pharmacological challenges, a correlation between the induced changes of the transcutaneously measured oxygen tension (PtcO2) and of conventional pulmonary function tests (PFTs) has been documented. We performed a 4-minute cold air challenge (CACh) in 17 children with bronchial asthma under continuous monitoring of PtcO2, and correlated observed changes with CACh-induced alterations of conventional PFTs. PtcO2 decreased significantly with CACh (from 86 +/- 10 mmHg to 66 +/- 14 mmHg, P less than 0.001), but returned to near-baseline within the next 30 minutes. PFTs changed with a similar pattern; the closest correlation was found between the CACh-induced fall of PtcO2 and Delta-FEV1 (r = 0.833, P less than 0.001). Changes of FVC, PEF, and Vmax50 correlated significantly as well. PtcO2 can complement or substitute for conventional PFTs in assessing the response to CACh in children.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Air -; Asthma - blood; Blood Gas Monitoring, Transcutaneous - methods; Bronchial Provocation Tests - methods; Child - methods; Cold - diagnostic use; Female - diagnostic use; Humans - diagnostic use; Lung - physiopathology; Male - physiopathology; Pulmonary Ventilation - physiology; Respiration - physiology; Time Factors - physiology
Find related publications in this database (Keywords): Childhood Asthma; Transcutaneous Po2 Monitoring; Pneumotachographic Spirometry; Ventilation-Perfusion Mismatching