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Selected Publication:
Peters, G; Gongoll, S; Langner, C; Mengel, M; Piso, P; Klempnauer, J; Rüschoff, J; Kreipe, H; von Wasielewski, R.
IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer.
Virchows Arch. 2003; 443(2):139-145
Doi: 10.1007/s00428-003-0856-5
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- Langner Cord
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- Abstract:
- Insulin-like growth factors (IGF-1 and IGF-2) and the IGF-1 membrane receptor (IGF-1R) have been found to play a critical role in the carcinogenesis of several tumors, among them colorectal cancer (CRC). To study the prognostic impact of these molecules, a total number of 713 cases of CRC were examined for the expression of IGF-1, IGF-2, and IGF-1R. The results were correlated with other clinicopathological data and clinical follow-up. IGF-1 expression was noted in 53 (7.5%), IGF-2 in 88 (12.6%), and IGF-1R in 698 (99.6%) of the cases. There were significant associations between the two growth factors ( P<0.00001), between IGF-1 and Ki-67 proliferation activity ( P<0.05), and between IGF-2 and tumor stage ( P<0.005). IGF-2 positivity was significantly correlated to a worse clinical outcome ( P<0.005) only in univariate, but not in multivariate, survival analysis. A similar trend was obtained for patients with IGF-1-positive CRC, but reached statistical significance only in limited tumor stages (pT1/pT2; P<0.01). Although the synchronous expression of IGF-1, IGF-2, and IGF-1R in a subset of CRC is consistent with an auto-/paracrine loop of cancer cell autostimulation, the prognostic effect of IGF-1 and IGF-2 expression seems to be of limited value. However, the identification of IGF-positive CRC might be beneficial for predictive reasons, as new molecular therapeutic approaches are aimed at the IGF system and related pathways.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - metabolism
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- Female - metabolism
- Humans - metabolism
- Insulin-Like Growth Factor II - metabolism
- Intercellular Signaling Peptides and Proteins - metabolism
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- Receptor, IGF Type 1 - metabolism
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- Find related publications in this database (Keywords)
- insulin-like growth factors
- IGF-1 receptor
- colon
- cancer
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