Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Langsenlehner, U; Krippl, P; Renner, W; Yazdani-Biuki, B; Wolf, G; Wascher, TC; Paulweber, B; Weitzer, W; Samonigg, H.
The common 677C>T gene polymorphism of methylenetetrahydrofolate reductase gene is not associated with breast cancer risk.
Breast Cancer Res Treat. 2003; 81(2):169-172
Doi: 10.1023/A:1025752420309
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Langsenlehner Uwe
- Co-Autor*innen der Med Uni Graz
- Krippl Peter
- Renner Wilfried
- Samonigg Hellmut
- Wascher Thomas
- Weitzer Werner
- Yazdani-Biuki Babak
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- Abstract:
- Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and plays a role in DNA biosynthesis, methylation, and repair in actively dividing cells. A common 677C>T polymorphism in the gene for MTHFR, leading to a thermolabile enzyme with decreased activity, has been associated with reduced plasma folate levels and elevated homocysteine levels and could be a risk factor for breast cancer. In the present case-control study, MTHFR genotype was determined in 500 women with clinically verified breast cancer and 500 female age-matched healthy control subjects. The homozygous TT genotype was found in 13.0% patients and 13.1% controls (P = n.s.). The odds ratio of TT homozygotes for breast cancer was 0.99 (95% confidence interval 0.68-1.43). The MTHFR genotype was furthermore not associated with tumor size, histological grading, estrogen or progesterone receptor status and age at diagnosis. In a subgroup of 116 premenopausal patients, no increased frequency of the homozygous 677T genotype was found (13.8%). Therefore, we conclude that the MTHFR 677C>T polymorphism is not associated with individual susceptibility to breast cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Breast Neoplasms - enzymology
- Carcinoma, Ductal, Breast - enzymology
- Case-Control Studies - enzymology
- Cytosine - metabolism
- Female - metabolism
- Genotype - metabolism
- Humans - metabolism
- Methylenetetrahydrofolate Reductase (NADPH2) - genetics
- Middle Aged - genetics
- Polymerase Chain Reaction - genetics
- Polymorphism, Genetic - genetics
- Risk Factors - genetics
- Thymine - metabolism
- Find related publications in this database (Keywords)
- breast cancer
- epidemiology
- genetics
- methylenetetrahydrofolate reductase
- MTHFR 677C > T polymorphism