Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Bjelic-Radisic, V; Stöger, H; Winter, R; Beham-Schmid, C; Petru, E.
Long-term control of bone marrow carcinosis and severe thrombocytopenia with standard-dose chemotherapy in a breast cancer patient: a case report.
Anticancer Res. 2006; 26(2B):1627-1630
(- Case Report)
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- Leading authors Med Uni Graz
- Bjelic-Radisic Vesna
- Co-authors Med Uni Graz
- Beham-Schmid Christine
- Petru Edgar
- Stöger Herbert
- Winter Raimund
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- Abstract:
- Primary metastatic breast cancer with bone marrow involvement and pronounced thrombocytopenia is rare. The myelosuppressive effect of most cytotoxic drugs limits chemotherapy in patients with cytopenia due to marrow involvement. A 62-year-old patient, who presented with locally and systemically advanced breast cancer, is reported. The initial work-up revealed bone marrow carcinosis with thrombocytopenia of less than 20,000/mm3 lung and osseous metastases without signs of suppressed erythropoiesis and leucopoiesis. The patient was stabilized with 6 different standard-dose chemotherapy regimens, antihormonal therapy, and trastuzumab before dying 57 months after first diagnosis. The patient received only platelet transfusions on 2 instances with platelets of 2,000/mm3. This case illustrates that aggressive standard chemotherapy may be feasible in selected patients with bone marrow carcinosis-associated thrombocytopenia without major bleeding episodes.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Bone Marrow - pathology
- Breast Neoplasms - blood
- Breast Neoplasms - drug therapy
- Breast Neoplasms - pathology
- Female -
- Humans -
- Middle Aged -
- Thrombocytopenia - complications
- Thrombocytopenia - pathology
- Find related publications in this database (Keywords)
- bone marrow carcinosis
- thrombocytopenia
- metastatic breast cancer
- antihormonal therapy
- trastuzumab