Medizinische Universität Graz - Research portal
Selected Publication:
Wascher, TC; Boes, U.
Ischemia in type 2 diabetes: tissue selectivity of sulfonylureas and clinical implications.
Metabolism. 2003; 52(8 Suppl 1):3-5
Doi: 10.1016/S0026-0495(03)00211-7
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Leading authors Med Uni Graz
- Wascher Thomas
- Co-authors Med Uni Graz
- Aldenhoff Ursula
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Sulfonylureas act by inhibition of beta-cell adenosine triphosphate-dependent potassium (K(ATP)) channels after binding to the sulfonylurea subunit 1 receptor (SUR1). However, K(ATP) channels are also expressed in cardiac and vascular myocytes coupled to different receptor subtypes. These are thought to be involved in adaption of vascular tone and myocardial contractility. This brief review is intended to assess the interactions between sulfonylureas and extrapancreatic K(ATP) receptors in type 2 diabetic patients. Different models addressing the possible influence of sulfonylureas on vascular function are discussed.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenosine Triphosphate - metabolism
- Diabetes Mellitus, Type 2 - complications
- Diabetic Angiopathies - etiology Diabetic Angiopathies - physiopathology
- Humans -
- Potassium Channels - drug effects
- Sulfonylurea Compounds - adverse effects Sulfonylurea Compounds - pharmacology
- Vasomotor System - drug effects