Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Weger, M; Renner, W; Pinter, O; Stanger, O; Temmel, W; Fellner, P; Schmut, O; Haas, A.
Role of factor V Leiden and prothrombin 20210A in patients with retinal artery occlusion.
Eye. 2003; 17(6):731-734
Doi: 10.1038/sj.eye.6700495
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- Führende Autor*innen der Med Uni Graz
- Weger Martin
- Co-Autor*innen der Med Uni Graz
- Haas Anton
- Renner Wilfried
- Schmut Otto
- Temmel Werner
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- Abstract:
- PURPOSE: Retinal artery occlusion is a common vision-threatening disease. Among other risk factors, coagulopathies leading to a hypercoagulable state have been associated with retinal artery occlusion. Numerous studies have shown that two genetic variants, factor V Leiden and prothrombin 20210A, cause a procoagulant state. However, their role in the pathogenesis of retinal artery occlusion is still unclear. The purpose of the present study was therefore to investigate a possible association between factor V Leiden, prothrombin 20210A, and retinal artery occlusion. METHODS: In the present retrospective case-control study, we studied 136 patients with retinal artery occlusion and 136 age- and gender-matched control subjects. The presence of factor V Leiden and prothrombin 20210A alleles was determined by polymerase chain reaction. RESULTS: The prevalence of heterozygosity for the prothrombin G20210A variant did not significantly differ between patients and controls (three patients vs two controls, P=0.65). Distribution of factor V Leiden genotypes revealed no significant difference among the two groups (heterozygosity: eight patients vs 11 controls, P=0.47). As for other risk factors, arterial hypertension, a history of stroke and myocardial infarction were significantly more frequent in patients than in controls. CONCLUSION: Our data suggest that factor V Leiden and prothrombin 20210A do not play a major role in patients with retinal artery occlusion.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Alleles -
- Cardiovascular Diseases - complications
- Case-Control Studies - complications
- Factor V - genetics
- Female - genetics
- Genotype - genetics
- Heterozygote - genetics
- Humans - genetics
- Male - genetics
- Middle Aged - genetics
- Prothrombin - genetics
- Retinal Artery Occlusion - etiology
- Risk Factors - etiology
- Find related publications in this database (Keywords)
- retinal artery occlusion
- factor V Leiden
- prothrombin 20210A
- risk factor