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SHR Neuro Cancer Cardio Lipid Metab Microb
Hofer, A; Hassan, AS; Legat, FJ; Kerl, H; Wolf, P.
The efficacy of excimer laser (308 nm) for vitiligo at different body sites.
J Eur Acad Dermatol Venereol. 2006; 20(5):558-564
Doi: 10.1111/j.1468-3083.2006.01547.x
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- Leading authors Med Uni Graz
- Hofer Angelika
- Co-authors Med Uni Graz
- Kerl Helmut
- Legat Franz
- Wolf Peter
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- Abstract:
- The treatment with XeCl-excimer laser generated 308-nm UVB radiation has shown promising results in patients with vitiligo. In this controlled, prospective trial we studied the primary efficacy (start and grade of repigmentation) and patient's satisfaction of XeCl-excimer laser for treatment of vitiligo patches at different body sites and re-evaluated the achieved repigmentation 12 months after the end of therapy. Twenty-five patients with generalized or localized vitiligo with a total of 85 lesions at different body sites were enrolled in this study. Vitiligo patches were treated with 308-nm XeCl-excimer laser 3 times a week for 6 to 10 weeks. The overall repigmentation grade of each treated lesion was evaluated once a week on a 5 point scale rating from 0 (no repigmentation), 1 (1-5%), 2 (6-25%), 3 (26-50%), 4 (51-75%), to 5 (76-100%). Twenty-four patients completed the study. Within 6 to 10 weeks of treatment 67% of the patients (16/24) developed follicular repigmentation of at least one of their vitiligo lesions. Lesion repigmentation started after a mean of 13 treatments in lesions located on the face, trunk, arm, and/or leg (high-responder location), and after a mean of 22 treatments in lesions located on the elbow, wrist, dorsum of the hand, knee, and/or dorsum of the foot (low-responder location). Untreated control lesions and lesions located on the fingers did not achieve any repigmentation. After 10 weeks of treatment repigmentation of more than 75% was found in 25% (7/28) of lesions of the high-responder location group versus 2% (1/43) of lesions of the low-responder location group. In most cases, laser-induced repigmentation was persistent, as determined 12 months after the end of treatment. 308-nm excimer laser is an effective modality for the treatment of vitiligo. However, similar to other non-surgical treatment modalities, the therapeutic effect is mainly dependent on the location of vitiligo lesions.
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- Find related publications in this database (Keywords)
- excimer laser
- follow-up
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- therapy
- vitiligo