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SHR Neuro Cancer Cardio Lipid Metab Microb

Mossbock, G; Weger, M; Faschinger, C; Steinbrugger, I; Temmel, W; Schmut, O; Renner, W; Hufnagel, C; Stanger, O.
Methylenetetrahydrofolatereductase (MTHFR) 677C>T polymorphism and open angle glaucoma.
MOL VIS. 2006; 12(11): 356-359. [OPEN ACCESS]
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Leading authors Med Uni Graz: Mossböck Georg
Co-authors Med Uni Graz: Faschinger Christoph; Renner Wilfried; Schmut Otto; Steinbrugger Iris; Temmel Werner; Weger Martin
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Abstract:: Purpose: Increased plasma homocysteine levels have been found in patients with primary open angle glaucoma (POAG) and glaucoma secondary to pseudoexfoliation syndrome (PEXG). A common polymorphism of the methylenetetrahydrofolatereductase (MTHFR 677C > T) leads to moderately elevated plasma homocysteine levels particularly under conditions of impaired folate status. It was the aim of this study to investigate a hypothesized association between this polymorphism and the presence of either POAG or PEXG. Methods: The present retrospective case-control study included a total of 553 participants comprising 204 patients with POAG, 138 patients with PEXG, and 211 control subjects. Genotyping for the MTHFR 677C > T polymorphism was performed by polymerase chain reaction (PCR). Results: No significant difference in the genotype distribution of the MTHFR 677C > T polymorphism was found between control subjects and patients with POAG or PEXG. The prevalence of the MTHFR 677TT genotype was 6.9% in patients with POAG, 11.6% in patients with PEXG, and 9.5% in control subjects. Conclusions: The present data suggest that the MTHFR 677C > T polymorphism itself is not a major genetic risk factor for POAG and PEXG in a central European population.
Find related publications in this database (using NLM MeSH Indexing): Aged -; Aged, 80 and over -; Case-Control Studies -; Cytosine -; Exfoliation Syndrome - genetics; Female -; Gene Frequency -; Genetic Predisposition to Disease -; Genotype -; Glaucoma, Open-Angle - genetics; Humans -; Male -; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Odds Ratio -; Polymorphism, Genetic -; Thymine -