Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mossbock, G; Weger, M; Faschinger, C; Steinbrugger, I; Temmel, W; Schmut, O; Renner, W; Hufnagel, C; Stanger, O.
Methylenetetrahydrofolatereductase (MTHFR) 677C>T polymorphism and open angle glaucoma.
MOL VIS. 2006; 12(11): 356-359.
[OPEN ACCESS]
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Mossböck Georg
- Co-Autor*innen der Med Uni Graz
- Faschinger Christoph
- Renner Wilfried
- Schmut Otto
- Steinbrugger Iris
- Temmel Werner
- Weger Martin
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Abstract:
- Purpose: Increased plasma homocysteine levels have been found in patients with primary open angle glaucoma (POAG) and glaucoma secondary to pseudoexfoliation syndrome (PEXG). A common polymorphism of the methylenetetrahydrofolatereductase (MTHFR 677C > T) leads to moderately elevated plasma homocysteine levels particularly under conditions of impaired folate status. It was the aim of this study to investigate a hypothesized association between this polymorphism and the presence of either POAG or PEXG. Methods: The present retrospective case-control study included a total of 553 participants comprising 204 patients with POAG, 138 patients with PEXG, and 211 control subjects. Genotyping for the MTHFR 677C > T polymorphism was performed by polymerase chain reaction (PCR). Results: No significant difference in the genotype distribution of the MTHFR 677C > T polymorphism was found between control subjects and patients with POAG or PEXG. The prevalence of the MTHFR 677TT genotype was 6.9% in patients with POAG, 11.6% in patients with PEXG, and 9.5% in control subjects. Conclusions: The present data suggest that the MTHFR 677C > T polymorphism itself is not a major genetic risk factor for POAG and PEXG in a central European population.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Case-Control Studies -
- Cytosine -
- Exfoliation Syndrome - genetics
- Female -
- Gene Frequency -
- Genetic Predisposition to Disease -
- Genotype -
- Glaucoma, Open-Angle - genetics
- Humans -
- Male -
- Methylenetetrahydrofolate Reductase (NADPH2) - genetics
- Odds Ratio -
- Polymorphism, Genetic -
- Thymine -