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Legat, FJ; Wolf, P.
Photodamage to the cutaneous sensory nerves: role in photoaging and carcinogenesis of the skin?
Photochem Photobiol Sci. 2006; 5(2):170-176 Doi: 10.1039/b508856a
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Leading authors Med Uni Graz: Legat Franz
Co-authors Med Uni Graz: Wolf Peter
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Abstract:: Chronic exposure to ultraviolet radiation (UVR) plays a significant role in aging and carcinogenesis of the skin. Sensory nerve fibers densely innervate all layers of the skin and get in close anatomical as well as functional contact with cellular components of the epidermis and dermis. In this review, we address the impact of acute and chronic UVR exposure on the cutaneous sensory nervous system and its mediators. We suggest that skin cell-derived nerve growth factor (NGF) and skin nerve-derived neuropeptides such as substance P (SP) and calcitonin gene-related peptide (CGRP) may play a central role in intrinsic aging as well as extrinsic (photo-) aging of the skin. In addition, we discuss the possible role of these mediators in photocarcinogenesis.
Find related publications in this database (using NLM MeSH Indexing): Humans -; Neoplasms, Radiation-Induced - etiology; Neurons, Afferent - radiation effects; Skin - innervation; Skin - pathology; Skin - radiation effects; Skin Aging - pathology; Skin Aging - radiation effects; Skin Neoplasms - etiology; Ultraviolet Rays - adverse effects